A systematic strategy for preparation of uncommon sugars through enzymatic resolution and ring-closing metathesis

被引：27
作者：
Zhu, LH [1 ]
Kedenburg, JP [1 ]
Xian, M [1 ]
Wang, PG [1 ]
机构：
[1] Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 05期
基金：
美国国家科学基金会;
关键词：
uncommon sugars; enzymatic resolution; ring-closing metathesis;
D O I：
10.1016/j.tetlet.2004.12.014
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A systematic synthetic strategy has been developed for producing uncommon sugars. This method involved kinetic resolution allylic alcohol followed by ring-closing-metathesis (RCM) to generate optical pure lactones as the common precursors. After further derivatization, four representative uncommon sugar units were successfully synthesized. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：811 / 813
页数：3
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