Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto's Thyroiditis

被引：0

作者：

Esfahanian, Fatemeh ^{[1
]}

Hazaveh, Mojgan Mirabdolhagh ^{[2
]}

Garehbagh, Laya Hooshmand ^{[1
]}

Falahati, Kowsar ^{[3
]}

Ataei, Mitra ^{[3
]}

Sanati, Mohammad Hossein ^{[3
]}

Jadali, Zohreh ^{[4
]}

机构：

[1] Univ Tehran Med Sci, Dept Endocrinol, Imam Khomeini Hosp Complex, Tehran, Iran

[2] Univ Tehran Med Sci, Sina Hosp, Dept Internal Med, Tehran, Iran

[3] Natl Inst Genet Engn & Biotechnol, Clin Genet Dept, Tehran, Iran

[4] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran

来源：

IRANIAN JOURNAL OF PUBLIC HEALTH | 2021年 / 50卷 / 08期

关键词：

DNA; Mitochondrial; Hashimoto's thyroiditis; Oxidative stress; Autoimmunity; ESCHERICHIA-COLI; CYTOCHROME-C; HORMONE; STRESS; RAT; 8-OHDG; LIVER; MAINTENANCE; EXPRESSION; BIOMARKERS;

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto's thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.

引用

页码：1697 / 1704

页数：8

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