Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimoto's Thyroiditis

被引：0
作者：
Esfahanian, Fatemeh [1 ]
Hazaveh, Mojgan Mirabdolhagh [2 ]
Garehbagh, Laya Hooshmand [1 ]
Falahati, Kowsar [3 ]
Ataei, Mitra [3 ]
Sanati, Mohammad Hossein [3 ]
Jadali, Zohreh [4 ]
机构：
[1] Univ Tehran Med Sci, Dept Endocrinol, Imam Khomeini Hosp Complex, Tehran, Iran
[2] Univ Tehran Med Sci, Sina Hosp, Dept Internal Med, Tehran, Iran
[3] Natl Inst Genet Engn & Biotechnol, Clin Genet Dept, Tehran, Iran
[4] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran
来源：
IRANIAN JOURNAL OF PUBLIC HEALTH | 2021年 / 50卷 / 08期
关键词：
DNA; Mitochondrial; Hashimoto's thyroiditis; Oxidative stress; Autoimmunity; ESCHERICHIA-COLI; CYTOCHROME-C; HORMONE; STRESS; RAT; 8-OHDG; LIVER; MAINTENANCE; EXPRESSION; BIOMARKERS;
D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Background: The purpose of present study was to investigate mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto's thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and oxidative stress in the pathophysiology of HT.
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页码：1697 / 1704
页数：8
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