Vasorelaxant effects of forsythiaside from the fruits of Forsythia suspensa

被引：20
|
作者：
Iizuka, T [1 ]
Nagai, M [1 ]
机构：
[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2005年 / 125卷 / 02期
关键词：
forsythiaside; Forsythia suspensa; vasorelaxant effects; receptor-operated Ca2+-channels;
D O I：
10.1248/yakushi.125.219
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The vasorelaxant effects of forsythiaside (compound 1) from the fruits of Forsythia suspensa on isolated rat aortic rings were studied. Compound 1 showed a slow relaxation activity against norepinephrine (NE)-induced contractions of rat aorta with/without endothelium. This compound did not affect contractions induced by a high concentration of potassium (K+ 60 mm), while it inhibited NE-induced vasocontraction in the presence of nicardipine. These results show that the inhibition by compound 1 of NE-induced vasocontraction is due to a decrease in calcium influx from the extracellular space caused by NE.
引用
收藏
页码：219 / 224
页数：6
相关论文
共 50 条
  • [1] Lignans from the fruits of Forsythia suspensa
    Piao, Xiang-Lan
    Jang, Moon Hee
    Cui, Jian
    Piao, Xiangshu
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (06) : 1980 - 1984
  • [2] STUDIES ON THE CHINESE CRUDE DRUG FORSYTHIAE FRUITS .5. THE STRUCTURE OF FORSYTHIASIDE ISOLATED FROM FORSYTHIA-SUSPENSA
    NISHIBE, S
    OKABE, K
    TSUKAMOTO, H
    SAKUSHIMA, A
    HISADA, S
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1982, 30 (03) : 1048 - 1050
  • [3] Dammarane derivatives from the dried fruits of Forsythia suspensa
    Rouf, ASS
    Ozaki, Y
    Rashid, MA
    Rui, J
    PHYTOCHEMISTRY, 2001, 56 (08) : 815 - 818
  • [4] Two new lignans from the fruits of Forsythia suspensa
    Cao, Jun
    Shao, Si-Yuan
    Zhang, Xu
    Yuan, Xiang
    Feng, Zi-Ming
    Jiang, Jian-Shuang
    Yang, Ya-Nan
    Zhang, Pei-Cheng
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2020, 22 (05) : 418 - 424
  • [5] Three New Compounds from the Fruits of Forsythia suspensa
    Zhang, Xu
    Shao, Siyuan
    Feng, Ziming
    Jiang, Jianshuang
    Yang, Ya'nan
    Zhang, Peicheng
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 41 (06) : 2496 - 2501
  • [6] Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa
    Qu, Huanhuan
    Zhang, Yongmin
    Wang, Yan
    Li, Baixue
    Sun, Wenji
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2008, 60 (02) : 261 - 266
  • [7] Chemical Constituents from the Fruits of Forsythia suspensa and Their Antimicrobial Activity
    Kuo, Ping-Chung
    Chen, Guo-Feng
    Yang, Mei-Lin
    Lin, Ya-Hua
    Peng, Chi-Chung
    BIOMED RESEARCH INTERNATIONAL, 2014, 2014
  • [8] Caffeoyl Phenylethanoid Glycosides from Unripe Fruits of Forsythia Suspensa
    Xia, Yong-Gang
    Yang, Bing-You
    Liang, Jun
    Kuang, Hai-Xue
    CHEMISTRY OF NATURAL COMPOUNDS, 2015, 51 (04) : 656 - 659
  • [9] Caffeoyl Phenylethanoid Glycosides from Unripe Fruits of Forsythia Suspensa
    Yong-Gang Xia
    Bing-You Yang
    Jun Liang
    Hai-Xue Kuang
    Chemistry of Natural Compounds, 2015, 51 : 656 - 659
  • [10] Chemical constituents from the fruits of Forsythia suspensa and their chemotaxonomic significance
    Liu, Sui
    Niu, Xiang-Xin
    He, Jun-Lei
    Yue, Chang-Hua
    Jiang, Zi-Xiao
    Yu, Zhang-Xin
    Liu, Yang-Yang
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2025, 120
12345