The Epidemiology and Diagnosis of Invasive Candidiasis Among Premature Infants

被引：97

作者：

Kelly, Matthew S. ^{[1
,2
]}

Benjamin, Daniel K., Jr. ^{[1
,2
]}

Smith, P. Brian ^{[1
,2
]}

机构：

[1] Duke Univ, Dept Pediat, Durham, NC 27710 USA

[2] Duke Clin Res Inst, Durham, NC 27705 USA

来源：

CLINICS IN PERINATOLOGY | 2015年 / 42卷 / 01期

关键词：

Neonatal candidiasis; Candida; Premature infants; Risk factors; INTENSIVE-CARE-UNIT; BIRTH-WEIGHT INFANTS; CENTRAL VENOUS CATHETERS; BLOOD-STREAM INFECTIONS; RISK-FACTORS; NEONATAL CANDIDIASIS; FUNGAL COLONIZATION; FLUCONAZOLE PROPHYLAXIS; RAPID IDENTIFICATION; ANTIMANNAN ANTIBODIES;

D O I：

10.1016/j.clp.2014.10.008

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Invasive candidiasis is a leading infectious cause of morbidity and mortality in premature infants. Improved recognition of modifiable risk factors and antifungal prophylaxis has contributed to the recent decline in the incidence of this infection among infants. Invasive candidiasis typically occurs in the first 6 weeks of life and presents with nonspecific signs of sepsis. Definitive diagnosis relies on the growth of Candida in blood culture or cultures from other normally sterile sites, but this may identify fewer than half of cases. Improved diagnostics are needed to guide the initiation of antifungal therapy in premature infants.

引用

页码：105 / +

页数：15

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