A feasibility study of the Tehran research reactor as a neutron source for BNCT

被引:23
作者
Kasesaz, Yaser [1 ]
Khalafi, Hossein [1 ]
Rahmani, Faezeh [2 ]
Ezati, Arsalan [1 ]
Keyvani, Mehdi [1 ]
Hossnirokh, Ashkan [1 ]
Shamami, Mehrdad Azizi [1 ]
Monshizadeh, Mandi [1 ]
机构
[1] Nucl Sci & Technol Res Inst, Tehran, Iran
[2] Shahid Beheshti Univ, Dept Radiat Applicat, Tehran, Iran
关键词
Tehran research reactor; BNCT; MCNP4C code; SAND-II code; Neutron spectrum measurement; Foil activation method; SKIN MELANOMA;
D O I
10.1016/j.apradiso.2014.03.028
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Investigation on the use of the Tehran Research Reactor (TRR) as a neutron source for Boron Neutron Capture Therapy (BNCT) has been performed by calculating and measuring energy spectrum and the spatial distribution of neutrons in all external irradiation facilities, including six beam tubes, thermal column, and the medical room. Activation methods with multiple foils and a copper wire have been used for the mentioned measurements. The results show that (1) the small diameter and long length beam tubes cannot provide sufficient neutron flux for BNCT; (2) in order to use the medical room, the TRR core should be placed in the open pool position, in this situation the distance between the core and patient position is about 400 cm, so neutron flux cannot be sufficient for BNCT; and (3) the best facility which can be adapted for BNCT application is the thermal column, if all graphite blocks can be removed. The epithermal and fast neutron flux at the beginning of this empty column are 4.12 x 10(9) and 1.21 x 10(9) n/cm(2)/s, respectively, which can provide an appropriate neutron beam for BNCT by designing and constructing a proper Beam Shaping Assembly (BSA) structure. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:132 / 137
页数:6
相关论文
共 11 条
  • [1] [Anonymous], 2001, IAEATECDOC1223
  • [2] BRIESMEISTER J. F., 2000, MCNP GEN MONTE CARLO
  • [3] First BNCT treatment of a skin melanoma in Argentina:: dosimetric analysis and clinical outcome
    González, SJ
    Bonomi, MR
    Cruz, GAS
    Blaumann, HR
    Larrieu, OAC
    Menéndez, P
    Rebagliati, RJ
    Longhino, J
    Feld, DB
    Dagrosa, MA
    Argerich, C
    Castiglia, SG
    Batistoni, DA
    Liberman, SJ
    Roth, BMC
    [J]. APPLIED RADIATION AND ISOTOPES, 2004, 61 (05) : 1101 - 1105
  • [4] Effectiveness of BNCT for recurrent head and neck malignancies
    Kato, I
    Ono, K
    Sakurai, Y
    Ohmae, M
    Maruhashi, A
    Imahori, Y
    Kirihata, M
    Nakazawa, M
    Yura, Y
    [J]. APPLIED RADIATION AND ISOTOPES, 2004, 61 (05) : 1069 - 1073
  • [5] McElroy W.N., 2002, RSIC COMPUTER CODE C, V112
  • [6] BNCT for skin melanoma in extremities: Updated Argentine clinical results
    Menendez, P. R.
    Roth, B. M. C.
    Pereira, M. D.
    Casal, M. R.
    Gonzalez, S. J.
    Feld, D. B.
    Santa Cruz, G. A.
    Kessler, J.
    Longhino, J.
    Blaumann, H.
    Jimenez Rebagliati, R.
    Calzetta Larrieu, O. A.
    Fernandez, C.
    Nievas, S. I.
    Liberman, S. J.
    [J]. APPLIED RADIATION AND ISOTOPES, 2009, 67 (7-8) : S50 - S53
  • [7] Spectrum shaping of accelerator-based neutron beams for BNCT
    Montagnini, B
    Cerullo, N
    Esposito, J
    Giusti, V
    Mattioda, F
    Varone, R
    [J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2002, 476 (1-2) : 90 - 98
  • [8] Clinical results of BNCT for malignant brain tumors in children
    Nakagawa, Yoshinobu
    Kageji, Teruyoshi
    Mizobuchi, Yoshifumi
    Kumada, Hiroaki
    Nakagawa, Yoshiaki
    [J]. APPLIED RADIATION AND ISOTOPES, 2009, 67 (7-8) : S27 - S30
  • [9] Beam shaping assembly optimization of Linac based BNCT and in-phantom depth dose distribution analysis of brain tumors for verification of a beam model
    Rahmani, Faezeh
    Shahriari, Majid
    [J]. ANNALS OF NUCLEAR ENERGY, 2011, 38 (2-3) : 404 - 409
  • [10] Radiologic findings in patients treated with boron neutron capture therapy for glioblastoma multiforme within eortc trial 11961
    Vos, MJ
    Turowski, B
    Zanella, FE
    Paquis, P
    Siefert, A
    Hideghety, K
    Haselsberger, K
    Grochulla, F
    Postma, TJ
    Wittig, A
    Heimans, JJ
    Slotman, BJ
    Vandertop, WP
    Sauerwein, W
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2005, 61 (02): : 392 - 399