Determination of degradation product of cefotaxime by differential pulse cathodic stripping voltammetry at silver microdisk electrode

被引：0

作者：

Zhang, YZ ^{[1
]}

Li, SP ^{[1
]}

Kan, XW ^{[1
]}

Li, MG ^{[1
]}

Feng, B ^{[1
]}

机构：

[1] Anhui Normal Univ, Dept Chem, Wuhu 241000, Peoples R China

来源：

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2000年 / 28卷 / 11期

关键词：

cefotaxime; degradation product; silver microdisk electrode; differential pulse cathodic; stripping voltammetry;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A differential pulse cathodic stripping voltammetry (DPCSV) has been established for the determination of cefotaxime(CTX) on silver microdisk electrode. The degradation product of CTX was carried out in 0.1 mol/L NaOH at 100 degreesC for 20 min. The method is based on the electrochemical behavior of the degradation product of CTX containing thiohydroxy group( - SH), which can combine with Ag+ to form an insoluble thiolate. In pH 4.5 NaAc-HAc medium a sensitive reduction peak of the degradation product of CTX was obtained at silver microdisk electrode with cyclic voltammetry. The reduction peak currents are proportional to the concentration of CTX in the range of 1.0 x 10(-7) similar to 1.0 x 10(-5) mol/L by DPCSV. This method has been successfully applied to the determination of CTX in simulant sample.

引用

页码：1371 / 1374

页数：4