Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus

被引：0

作者：

Silva, A. R. A.

Morais, S. M. ^{[1
]}

Marques, M. M. M.

Lima, D. M. ^{[2
]}

Santos, S. C. C. ^{[3
]}

Almeida, R. R. ^{[4
]}

Vieira, I. G. P. ^{[4
]}

Guedes, M. I. F. ^{[3
]}

机构：

[1] Univ Estadual Ceara, Lab Quim Prod Nat, Postgrad Program Biotechnol, BR-60740000 Fortaleza, Ceara, Brazil

[2] Univ Fortaleza, Ctr Hlth Sci, Fortaleza, Ceara, Brazil

[3] Univ Estadual Ceara, Biochem Lab, BR-60740000 Fortaleza, Ceara, Brazil

[4] Technol Dev Pk PADETEC, Fortaleza, Ceara, Brazil

来源：

JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES | 2011年 / 17卷 / 04期

关键词：

natural products; phenols; dengue; antiviral agents; IN-VITRO; TYPE-2; REPLICATION; MECHANISM; SURVIVAL; GROWTH; AGENTS; MOMBIN; RUTIN; ASSAY; CELL;

D O I：

暂无

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

In recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceara state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests were performed against type-2 dengue virus by the MTT method and standard cytopathic effect reduction assay in C(6/36) cells. Cytotoxicity was also evaluated by MTT. The presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by HPLC analysis. Both Spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with IC(50) of 362.68 mu g/mL and 500 mu g/mL, respectively.

引用

页码：406 / 413

页数：8

共 20 条

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