Palladium-Catalyzed Primary Amine-Directed Decarboxylative Annulation of α-Oxocarboxylic Acids: Access to Indolo[1,2-a]quinazolines

被引：35

作者：

Jiang, Guangbin ^{[1
]}

Wang, Shoucai ^{[1
]}

Zhang, Jun ^{[1
]}

Yu, Jianwen ^{[1
]}

Zhang, Ziang ^{[1
]}

Ji, Fanghua ^{[1
]}

机构：

[1] Guilin Univ Technol, Coll Chem & Bioengn, Guangxi Key Lab Electrochem & Magnetochem Funct M, Guilin 541004, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 08期

关键词：

palladium-catalyzed; alpha-oxocarboxylic acids; decarboxylative annulation; directing group; NITROGEN-CONTAINING HETEROCYCLES; O-METHYL KETOXIMES; C-H; ORTHO-ACYLATION; CARBOXYLIC-ACIDS; EFFICIENT SYNTHESIS; N-NITROSOANILINES; ARENES; AZOBENZENES; CYCLIZATION;

D O I：

10.1002/adsc.201900001

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient protocol for the preparation of indolo[1,2-a]quinazolines via palladium-catalyzed decarboxylative annulation of indols with alpha-oxocarboxylic acids has been realized by using primary amine as a directing group (DG). This transformation proceeds smoothly with exclusive regioselectivity and represents an one-pot Domino synthesis of indo-lo[1,2-a]quinazolines from alpha-oxocarboxylic acids.

引用

页码：1798 / 1802

页数：5

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