Extraversion and striatal dopaminergic receptor availability in young adults: an [18F]fallypride PET study

被引：15

作者：

Baik, Sang-hyun ^{[1
]}

Yoon, Heung Sik ^{[1
]}

Kim, Sang Eun ^{[2
]}

Kim, Sang Hee ^{[1
]}

机构：

[1] Korea Univ, Dept Brain & Cognit Engn, Seoul 136713, South Korea

[2] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Nucl Med, Seoul, South Korea

来源：

NEUROREPORT | 2012年 / 23卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

extraversion; F-18]fallypride; personality; positron emission tomography; striatum; PERSONALITY; NEUROTICISM;

D O I：

10.1097/WNR.0b013e3283507533

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Extraversion is a core personality trait associated with individual differences in reward sensitivity and has been linked to the dopaminergic brain system. We investigated whether dopaminergic receptor availability in the striatum was directly associated with individual differences in extraversion using the high-affinity radiotracer [F-18]fallypride and PET. Seventeen healthy male and female participants completed an [F-18]fallypride PET scan at rest. Extraversion was assessed using the revised Eysenck Personality Questionnaire. Dopamine receptor availability in predefined striatal regions of interest was assessed as [F-18]fallypride binding potential using a reference tissue model for [F-18]fallypride. Both region of interest and voxel-based whole-brain analyses showed that extraversion was significantly correlated with dopaminergic receptor availability in the striatum bilaterally. This finding contributes to our understanding of the dopaminergic neural mechanisms underlying individual differences in extraversion. NeuroReport 23:251-254 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：251 / 254

页数：4

共 24 条

[1]

[Anonymous], 2008, HDB PERSONALITY THEO

[2] An fMRI study of personality influences on brain reactivity to emotional stimuli [J].

Canli, T ;

Zhao, Z ;

Desmond, JE ;

Kang, EJ ;

Gross, J ;

Gabrieli, JDE .

BEHAVIORAL NEUROSCIENCE, 2001, 115 (01) :33-42

[3] Individual differences in extraversion and dopamine genetics predict neural reward responses [J].

Cohen, MX ;

Young, J ;

Baek, JM ;

Kessler, C ;

Ranganath, C .

COGNITIVE BRAIN RESEARCH, 2005, 25 (03) :851-861

[4] Regional cerebral brain metabolism correlates of neuroticism and extraversion [J].

Deckersbach, Thilo ;

Miller, Karen K. ;

Klibanski, Anne ;

Fischman, Alan ;

Dougherty, Darin D. ;

Blais, Mark A. ;

Herzog, David B. ;

Rauch, Scott L. .

DEPRESSION AND ANXIETY, 2006, 23 (03) :133-138

[5]

Depue RA, 1999, BEHAV BRAIN SCI, V22, P491

[6]

Eysenck H.J., 1993, Eysenck personality questionnairerevised (EPQR) Database record, DOI [DOI 10.1037/T05461-000, 10.1037/t05461-000]

[7] D2 dopamine receptors and personality traits [J].

Farde, L ;

Gustavsson, JP ;

Jonsson, E .

NATURE, 1997, 385 (6617) :590-590

[8] Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking [J].

Gjedde, Albert ;

Kumakura, Yoshitaka ;

Cumming, Paul ;

Linnet, Jakob ;

Moller, Arne .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (08) :3870-3875

[9] Relationship between dopamine system genes and extraversion and novelty seeking [J].

Golimbet V.E. ;

Alfimova M.V. ;

Gritsenko I.K. ;

Ebstein R.P. .

Neuroscience and Behavioral Physiology, 2007, 37 (6) :601-606

[10] Parametric imaging of ligand-receptor binding in PET using a simplified reference region model [J].

Gunn, RN ;

Lammertsma, AA ;

Hume, SP ;

Cunningham, VJ .

NEUROIMAGE, 1997, 6 (04) :279-287

← 1 2 3 →