Ti-Catalyzed Multicomponent Oxidative Carboamination of Alkynes with Alkenes and Diazenes

被引：55

作者：

Davis-Gilbert, Zachary W. ^{[1
]}

Yao, Letitia J. ^{[1
]}

Tonks, Ian A. ^{[1
]}

机构：

[1] Univ Minnesota Twin Cities, Dept Chem, 207 Pleasant St SE, Minneapolis, MN 55455 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 44期

基金：

美国国家卫生研究院;

关键词：

REDUCTIVE ELIMINATION; COMPLEXES; IMINES; BONDS; CYCLOADDITION; ADDITIONS; CARBON; TI(IV);

D O I：

10.1021/jacs.6b09939

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The inter- or intramolecular oxidative carboamination of alkynes catalyzed by [py(2)TiCl(2)NPh](2) is reported. These multicomponent reactions couple alkenes, alkynes and diazenes to form either alpha,beta-unsaturated imines or alpha-(iminomethyl)cyclopropanes via a Ti-II/Ti-IV redox cycle. Each of these products is formed from a common azatitanacyclohexene intermediate that undergoes either beta-H elimination or alpha,gamma-coupling, wherein the selectivity is under substrate control.

引用

页码：14570 / 14573

页数：4

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