Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum

被引：37

作者：

Roberts, Lindi ^{[1
]}

Egan, Timothy J. ^{[1
,2
]}

Joiner, Keith A. ^{[1
,3
,4
,5
]}

Hoppe, Heinrich C. ^{[1
,6
]}

机构：

[1] Univ Cape Town, Sch Med, Div Pharmacol, Observ 7925, ZA-7925 Cape Town, South Africa

[2] Univ Cape Town, Dept Chem, ZA-7925 Cape Town, South Africa

[3] Univ Arizona, Sch Med, Dept Med, Tucson, AZ 85721 USA

[4] Univ Arizona, Sch Med, Dept Cell Biol, Tucson, AZ 85721 USA

[5] Univ Arizona, Sch Med, Dept Anat, Tucson, AZ 85721 USA

[6] CSIR, Biosci Div, ZA-0001 Pretoria, South Africa

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1128/AAC.01478-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of quinoline antimalarials on endocytosis by Plasmodium falciparum was investigated by measuring parasite hemoglobin levels, peroxidase uptake, and transport vesicle content. Mefloquine, quinine, and hallofantrine inhibited endocytosis, and chloroquine inhibited vesicle trafficking, while amodiaquine shared both effects. Protease inhibitors moderated hemoglobin perturbations, suggesting a common role for heme binding.

引用

页码：1840 / 1842

页数：3

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