Enantioselective Total Synthesis of (S)-Bisoranjidiol, an Axially Chiral Bisanthraquinone

被引：42
|
作者：
Podlesny, Erin E. [1 ]
Kozlowski, Marisa C. [1 ]
机构：
[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 06期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
BINAPHTHYL POLYMERS; STEREOCHEMISTRY; COMPLEXES; PIGMENTS; TANDEM;
D O I：
10.1021/ol3001365
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first enantioselective total synthesis of the bisanthraquinone (S)-bisoranjidiol and an unnatural regioisomer has been accomplished. Key features of the synthesis include the asymmetric oxidative biaryl coupling of a hindered 8-substituted 2-naphthol, selective para-quinone formation, and regioselective tandem Diels-Alder/aromatization reactions.
引用
收藏
页码：1408 / 1411
页数：4
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