Late-onset life threatening hemorrhage of omeprazole-resistant duodenal ulcer managed by interventional radiology: Report of a case

被引：1

作者：

Hizawa, Kazuoki ^{[1
]}

Miura, Nobutoshi ^{[2
]}

Hasegawa, Hirofumi ^{[3
]}

Kitamura, Masayuki ^{[3
]}

Nakamori, Mari ^{[4
]}

Matsumoto, Takayuki ^{[5
]}

Iida, Mitsuo ^{[5
]}

机构：

[1] Kyushu Cent Hosp, Dept Internal Med, Minami Ku, Fukuoka 8158588, Japan

[2] Kyushu Cent Hosp, Dept Radiol, Fukuoka 8158588, Japan

[3] Kyushu Cent Hosp, Dept Surg, Fukuoka 8158588, Japan

[4] Kyushu Cent Hosp, Dept Pathol, Fukuoka 8158588, Japan

[5] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka 812, Japan

来源：

INTERNAL MEDICINE | 2006年 / 45卷 / 14期

关键词：

interventional radiology; omeprazole resistant peptic ulcer; extensive metabolizer of CYP2C19; hemorrhagic duodenal ulcer; endoscopic hemostasis;

D O I：

10.2169/internalmedicine.45.1721

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 67-year-old diabetic man was emergently hospitalized in our department because of a huge duodenal ulcer without visible vessels. Despite of intravenous administration of 40 mg omeprazole and fasting with intravenous nutritional support, endoscopically unmanageable massive bleeding occurred on the 8th hospital day. Emergent angiography showed extravasation of contrast media from a duodenal branch of the proper hepatic artery, and superselective arterial embolization was successfully achieved. The patient recovered from the hemorrhagic shock and underwent subsequent successful surgery. Analysis of CYP2C19 enzyme genotype indicated the patient was a homozygous extensive metabolizer, considered a poor responder for omeprazole treatment.

引用

页码：861 / 863

页数：3

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