Substrate scope for trimethyllysine hydroxylase catalysis

被引：17
|
作者：
Al Temimi, Abbas H. K. [1 ]
Pieters, Bas J. G. E. [1 ]
Reddy, Y. Vijayendar [1 ]
White, Paul B. [1 ]
Mecinovic, Jasmin [1 ]
机构：
[1] Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 87期
关键词：
GAMMA-BUTYROBETAINE HYDROXYLASE; EPSILON-N-TRIMETHYLLYSINE; CARNITINE BIOSYNTHESIS; 3-HYDROXY-N6-TRIMETHYL-LYSINE; N6-TRIMETHYL-LYSINE; METABOLISM;
D O I：
10.1039/c6cc07845a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Trimethyllysine hydroxylase (TMLH) is a non-haem Fe(II) and 2-oxoglutarate dependent oxygenase that catalyses the C-3 hydroxylation of an unactivated C-H bond in L-trimethyllysine in the first step of carnitine biosynthesis. The examination of trimethyllysine analogues as substrates for human TMLH reveals that the enzyme does hydroxylate substrates other than natural L-trimethyllysine.
引用
收藏
页码：12849 / 12852
页数：4
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