Future trends in screening technology for drug discovery

被引:2
作者
Scheer, Alexander [1 ]
机构
[1] Serono Pharmaceut Res Inst, Dept Mol Screening & Cellular Pharmacol, Geneva, CH, Switzerland
关键词
affinity based screening; cellular imaging; high-throughput screening;
D O I
10.1517/17460441.1.3.195
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The last decade showed a further upsurge in screening technology advance and innovation. Notably, the establishment of ultra high-throughput screening facilities led to an explosion of screening capacities. However, in the last 2 years, a turning point in screening philosophy can be observed worldwide. Increasingly more companies are reducing the size of screening campaigns, while increasing the emphasis on data quality and relevance. This article tries to investigate how screening technologies will develop in the ever-changing landscape of drug discovery.
引用
收藏
页码:195 / 198
页数:4
相关论文
共 15 条
  • [1] Fragment-based lead discovery: leads by design
    Carr, RAE
    Congreve, M
    Murray, CW
    Rees, DC
    [J]. DRUG DISCOVERY TODAY, 2005, 10 (14) : 987 - 992
  • [2] Cellular dielectric spectroscopy: A powerful new approach to label-free cellular analysis
    Ciambrone, GJ
    Liu, VF
    Lin, DC
    McGuinness, RP
    Leung, GK
    Pitchford, S
    [J]. JOURNAL OF BIOMOLECULAR SCREENING, 2004, 9 (06) : 467 - 480
  • [3] Comess KM, 2004, CURR OPIN DRUG DISC, V7, P411
  • [4] Structure-based design of cyclin-dependent kinase inhibitors
    Davies, TG
    Pratt, DJ
    Endicott, JA
    Johnson, LN
    Noble, MEM
    [J]. PHARMACOLOGY & THERAPEUTICS, 2002, 93 (2-3) : 125 - 133
  • [5] Comparison of on-chip and off-chip microfluidic kinase assay formats
    Dunne, J
    Reardon, H
    Trinh, V
    Li, E
    Farinas, J
    [J]. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2004, 2 (02) : 121 - 129
  • [6] Enzyme family-specific and activity-based screening of chemical libraries using enzyme microarrays
    Funeriu, DP
    Eppinger, J
    Denizot, L
    Miyake, M
    Miyake, J
    [J]. NATURE BIOTECHNOLOGY, 2005, 23 (05) : 622 - 627
  • [7] NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein
    Hajduk, PJ
    Dinges, J
    Miknis, GF
    Merlock, M
    Middleton, T
    Kempf, DJ
    Egan, DA
    Walter, KA
    Robins, TS
    Shuker, SB
    Holzman, TF
    Fesik, SW
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (20) : 3144 - 3150
  • [8] Microarrays for the functional analysis of the chemical-kinase interactome
    Horiuchi, KY
    Wang, Y
    Diamond, SL
    Ma, HC
    [J]. JOURNAL OF BIOMOLECULAR SCREENING, 2006, 11 (01) : 48 - 56
  • [9] Horrocks C, 2003, CURR OPIN DRUG DISC, V6, P570
  • [10] Application of division arrest technology to cell-based HTS: Comparison with frozen and fresh cells
    Kunapuli, P
    Zheng, W
    Weber, M
    Solly, K
    Mull, R
    Platchek, M
    Cong, M
    Zhong, Z
    Strulovici, B
    [J]. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES, 2005, 3 (01) : 17 - 26