Immunological Function of Sphingosine 1-Phosphate in the Intestine

被引：30
作者：
Kunisawa, Jun [1 ,2 ]
Kiyono, Hiroshi [1 ,2 ,3 ,4 ]
机构：
[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Mucosal Immunol, Tokyo 1088639, Japan
[2] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Chiba 2778562, Japan
[3] Univ Tokyo, Grad Sch Med, Tokyo 1130033, Japan
[4] Japan Sci & Technol Agcy, CREST, Tokyo 1020076, Japan
来源：
NUTRIENTS | 2012年 / 4卷 / 03期
关键词：
intestinal immunity; lipid; IgA antibody; intraepithelial T lymphocytes; food allergy; CD4; T-CELLS; LYMPHOCYTE EGRESS; IMMUNE REGULATION; EPITHELIAL-CELLS; RECEPTOR; S1P LYASE; SPHINGOSINE-1-PHOSPHATE; TRAFFICKING; FTY720; SPHINGOMYELIN;
D O I：
10.3390/nu4030154
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
It has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism.
引用
收藏
页码：154 / 166
页数：13
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