p-Aminophenyl Alkyl Ether-based 19F MRI Probe for Specific Detection and Imaging of Hypochlorite Ion

被引：14
作者：
Doura, Tomohiro [1 ]
An, Qi [1 ]
Sugihara, Fuminori [2 ]
Matsuda, Tetsuya [2 ]
Sando, Shinsuke [1 ,3 ]
机构：
[1] Kyushu Univ, INAMORI Frontier Res Ctr, Nishi Ku, Fukuoka 8190395, Japan
[2] Kyoto Univ, Dept Syst Sci, Grad Sch Informat, Sakyo Ku, Kyoto 6068501, Japan
[3] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan
来源：
CHEMISTRY LETTERS | 2011年 / 40卷 / 12期
关键词：
MYELOPEROXIDASE ACTIVITY; FLUORESCENCE PROBES; SYNOVIAL-FLUID; MECHANISM; REPORTER;
D O I：
10.1246/cl.2011.1357
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a F-19 MRI probe for the specific detection and imaging of -OCl. Our designed probe, having p-aminophenyl alkyl scaffold, reacted expeditiously with -OCl to produce a trifluoroethanol. Concomitant with the reaction, the F-19 chemical shift changed by 2.6 ppm, allowing the visualization of -OCl-dependent probe-to-product conversion using F-19 MRI.
引用
收藏
页码：1357 / 1359
页数：3
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