Emerging Roles and Therapeutic Interventions of Aerobic Glycolysis in Glioma

被引：31
作者：
Han, Wei [1 ]
Shi, Jia [1 ]
Cao, Jiachao [1 ]
Dong, Bo [1 ]
Guan, Wei [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 3, Dept Neurosurg, Changzhou, Jiangsu, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2020年 / 13卷
关键词：
aerobic glycolysis; glioma; biological roles; therapeutic interventions; clinical application; FACILITATIVE GLUCOSE-TRANSPORTER; UPPER GASTROINTESTINAL-TRACT; PYRUVATE-KINASE M2; GENE-EXPRESSION; C-MYC; MEMBRANE PERMEABILIZATION; INHIBITS GLYCOLYSIS; OXIDATIVE STRESS; MAMMALIAN TARGET; TUMOR GLYCOLYSIS;
D O I：
10.2147/OTT.S260376
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Glioma is the most common type of intracranial malignant tumor, with a great recurrence rate due to its infiltrative growth, treatment resistance, intra- and intertumoral genetic heterogeneity. Recently, accumulating studies have illustrated that activated aerobic glycolysis participated in various cellular and clinical activities of glioma, thus influencing the efficacy of radiotherapy and chemotherapy. However, the glycolytic process is too complicated and ambiguous to serve as a novel therapy for glioma. In this review, we generalized the implication of key enzymes, glucose transporters (GLUTs), signalings and transcription factors in the glycolytic process of glioma. In addition, we summarized therapeutic interventions via the above aspects and discussed promising clinical applications for glioma.
引用
收藏
页码：6937 / 6955
页数：19
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