A novel pyrene-based fluorescent probe for the rapid and efficient detection of Co2+ in HeLa cells and natural water samples

被引:25
作者
Zhu, Meiqing [1 ,2 ]
Wang, Wenliang [1 ]
Liu, Jia [1 ]
Na, Risong [1 ]
Li, Zhenfeng [3 ,4 ]
Wang, Yi [1 ,2 ,3 ,4 ]
机构
[1] Henan Agr Univ, Coll Plant Protect, Collaborat Innovat Ctr Henan Grain Crops, Natl Key Lab Wheat & Maize Crop Sci, Zhengzhou 450002, Peoples R China
[2] Anhui Agr Univ, Sch Resources & Environm, Dept Pesticide Sci, Key Lab Agrifood Safety Anhui Prov, Hefei 230036, Peoples R China
[3] Univ Calif Davis, Dept Entomol, Sch Vet Med, Davis, CA 95616 USA
[4] Univ Calif Davis, UCD Comprehens Canc Ctr, Sch Vet Med, Davis, CA 95616 USA
基金
中国国家自然科学基金;
关键词
Co2+; Application; Density functional theory; Imaging; COLORIMETRIC CHEMOSENSOR; SERUM-ALBUMIN; RECOGNITION; COBALT; SENSOR; CU2+; IONS; ENHANCEMENT; ZN2+;
D O I
10.1016/j.molliq.2020.112680
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Excessive levels of Co2+ in the environment can cause serious diseases to humans and affect the growth of crops. Therefore, it is necessary to develop effective methods for monitoring Co2+. In the present work, a novel, low-toxic fluorescent probe, PEPA, for the rapid and efficient detection of Co2+ is synthesized. PEPA shows high sensitivity, with a limit of detection of 0.104 mu M and a fast response to Co2+ (<4 min). The detection mechanism was confirmed by FT-IR. HRMS and DFT calculations. Co2+ can restrict the free rotation of the C=N group and the pyrazine ring of PEPA, resulting in the enhancement of fluorescence. In addition, the recognition process of Co2+ can be realized with the naked eye (i.e., a color change from colorless to blue fluorescence). The successful detection of Co2+ in test strips and environmental water samples provides strong support for its application potential. Interestingly, the recovery rate of Co2+ detected by PEPA can reach 93% after being recovered four times. Importantly, PEPA was suitable for the fluorescence imaging of exogenous Co2+ in HeLa cells. (C) 2020 Elsevier B.V. All rights reserved.
引用
收藏
页数:8
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