Evolution of networks and sequences in eukaryotic cell cycle control

被引:108
作者
Cross, Frederick R. [1 ]
Buchler, Nicolas E. [2 ,3 ,4 ]
Skotheim, Jan M. [5 ]
机构
[1] Rockefeller Univ, New York, NY 10065 USA
[2] Duke Univ, Dept Biol, Durham, NC 27708 USA
[3] Duke Univ, Dept Phys, Durham, NC 27708 USA
[4] Duke Univ, Inst Genome Sci & Policy, Durham, NC 27710 USA
[5] Stanford Univ, Dept Biol, Stanford, CA 94305 USA
关键词
cell cycle; eukaryotes; evolution; opisthokonts; plants; DNA-BINDING DOMAIN; BUDDING YEAST; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; DEPENDENT KINASES; G1; CYCLINS; SACCHAROMYCES-CEREVISIAE; G1-SPECIFIC TRANSCRIPTION; ARABIDOPSIS-THALIANA; FUNCTIONAL HOMOLOGS;
D O I
10.1098/rstb.2011.0078
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The molecular networks regulating the G1-S transition in budding yeast and mammals are strikingly similar in network structure. However, many of the individual proteins performing similar network roles appear to have unrelated amino acid sequences, suggesting either extremely rapid sequence evolution, or true polyphyly of proteins carrying out identical network roles. A yeast/mammal comparison suggests that network topology, and its associated dynamic properties, rather than regulatory proteins themselves may be the most important elements conserved through evolution. However, recent deep phylogenetic studies show that fungal and animal lineages are relatively closely related in the opisthokont branch of eukaryotes. The presence in plants of cell cycle regulators such as Rb, E2F and cyclins A and D, that appear lost in yeast, suggests cell cycle control in the last common ancestor of the eukaryotes was implemented with this set of regulatory proteins. Forward genetics in non-opisthokonts, such as plants or their green algal relatives, will provide direct information on cell cycle control in these organisms, and may elucidate the potentially more complex cell cycle control network of the last common eukaryotic ancestor.
引用
收藏
页码:3532 / 3544
页数:13
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