Clinical Implication of Phosphodiesterase-4-Inhibition

被引：56

作者：

Schick, Martin Alexander ^{[1
,2
]}

Schlegel, Nicolas ^{[3
]}

机构：

[1] Univ Freiburg, Med Ctr, Dept Anesthesiol & Crit Care, D-79106 Freiburg, Germany

[2] Univ Freiburg, Fac Med, D-79110 Freiburg, Germany

[3] Univ Hosp Wuerzburg, Dept Gen Visceral Transplant Vasc & Pediat Surg, D-97080 Wurzburg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期

关键词：

phosphodiesterase; phosphodiesterase-4; phosphodiesterase-inhibitors; PDE; PDE4-I; CAMP-SPECIFIC PHOSPHODIESTERASE; PDE4 INHIBITOR ROFLUMILAST; BRONCHIAL EPITHELIAL-CELLS; FORSKOLIN BINDING-SITES; CYCLIC-AMP; DIFFERENTIAL EXPRESSION; INFLAMMATORY RESPONSE; ENDOTHELIAL BARRIER; MOLECULAR-CLONING; ATOPIC-DERMATITIS;

D O I：

10.3390/ijms23031209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pleiotropic function of 3 ',5 '-cyclic adenosine monophosphate (cAMP)-dependent pathways in health and disease led to the development of pharmacological phosphodiesterase inhibitors (PDE-I) to attenuate cAMP degradation. While there are many isotypes of PDE, a predominant role of PDE4 is to regulate fundamental functions, including endothelial and epithelial barrier stability, modulation of inflammatory responses and cognitive and/or mood functions. This makes the use of PDE4-I an interesting tool for various therapeutic approaches. However, due to the presence of PDE4 in many tissues, there is a significant danger for serious side effects. Based on this, the aim of this review is to provide a comprehensive overview of the approaches and effects of PDE4-I for different therapeutic applications. In summary, despite many obstacles to use of PDE4-I for different therapeutic approaches, the current data warrant future research to utilize the therapeutic potential of phosphodiesterase 4 inhibition.

引用

页数：19

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