Biochemical and immunological markers of multiple sclerosis

被引：0

作者：

Seven, Arzu ^{[1
]}

Aslan, Mahmure ^{[1
]}

机构：

[1] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey

来源：

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI | 2007年 / 32卷 / 03期

关键词：

multiple sclerosis; biological marker; inflammation; demyelination; remyelination and repair; axonal damage; oxidative stress; immune system; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; FIBRILLARY ACIDIC PROTEIN; CEREBROSPINAL-FLUID; NEUROFILAMENT LIGHT; APOLIPOPROTEIN-E; B-CELLS; AUTOIMMUNE ENCEPHALOMYELITIS; BIOLOGICAL MARKERS; IMMUNE-RESPONSE; AXONAL DAMAGE;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple sclerosis is the most common neurological disease in young adults characterized by recurrent relapses and/ or progression within the central nervous system. It is a complex disease in which several pathophysiological mechanisms such as axonal/ neuronal damage, demyelination, inflammation, gliosis, remyelination and repair, oxidative stres and excitotoxicity, alteration of the immune system and disruption of blood- brain barrier are involved. Biological markers; reflecting the immunopathological process, indicating responses to therapeutic interventions and optimizing therapy; are needed for the development of process- specific therapies and the prevention of disability.

引用

页码：112 / 119

页数：8

共 81 条

[1] Roles of immunoglobulins and B cells in multiple sclerosis: From pathogenesis to treatment [J].

Antel, Jack ;

Bar-Or, Amit .

JOURNAL OF NEUROIMMUNOLOGY, 2006, 180 (1-2) :3-8

[2] The role of integrins in immune-mediated diseases of the nervous system [J].

Archelos, JJ ;

Previtali, SC ;

Hartung, HP .

TRENDS IN NEUROSCIENCES, 1999, 22 (01) :30-38

[3]

Archelos JJ, 2000, ANN NEUROL, V47, P694, DOI 10.1002/1531-8249(200006)47:6<694::AID-ANA2>3.3.CO

[4]

2-N

[5] Epstein-Barr virus antibodies and risk of multiple sclerosis -: A prospective study [J].

Ascherio, A ;

Munger, KL ;

Lennette, ET ;

Spiegelman, D ;

Hernán, MA ;

Olek, MJ ;

Hankinson, SE ;

Hunter, DJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (24) :3083-3088

[6] Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event [J].

Berger, T ;

Rubner, P ;

Schautzer, F ;

Egg, R ;

Ulmer, H ;

Mayringer, I ;

Dilitz, E ;

Deisenhammer, F ;

Reindl, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (02) :139-145

[7] Morphogenesis of the peri-implant mucosa: an experimental study in dogs [J].

Berglundh, Tord ;

Abrahamsson, Ingemar ;

Welander, Maria ;

Lang, Niklaus P. ;

Lindhe, Jan .

CLINICAL ORAL IMPLANTS RESEARCH, 2007, 18 (01) :1-8

[8] Development of biomarkers in multiple sclerosis [J].

Bielekova, B ;

Martin, R .

BRAIN, 2004, 127 :1463-1478

[9] Acute axonal injury in multiple sclerosis -: Correlation with demyelination and inflammation [J].

Bitsch, A ;

Schuchardt, J ;

Bunkowski, S ;

Kuhlmann, T ;

Brück, W .

BRAIN, 2000, 123 :1174-1183

[10] Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease [J].

Bjartmar, C ;

Wujek, JR ;

Trapp, BD .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2003, 206 (02) :165-171

← 1 2 3 4 5 6 7 8 9 →