18F-FDG PET/CT and MRI Findings in a Patient With Anti-GABAB Receptor Encephalitis

被引：11
作者：
Su, Minggang [1 ]
Xu, Dongkun [1 ]
Tian, Rong [1 ]
机构：
[1] Sichuan Univ, Natl Key Discipline Med Imaging & Nucl Med, Dept Nucl Med, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
来源：
CLINICAL NUCLEAR MEDICINE | 2015年 / 40卷 / 06期
关键词：
F-18-FDG PET/CT; MRI; autoimmune synaptic encephalitis; encephalitis; GABA(B);
D O I：
暂无
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Autoimmune synaptic encephalitis can occur as paraneoplastic neurological syndromes, which are dysfunctions of the nervous system in cancer patients. One such rare but treatable form is associated with GABA(B) (gamma-aminobutyric acid-B) receptor antibody. We report a 55-year-old man with small cell lung cancer who presented with 3 weeks of progressive seizures, memory impairment, and behavioral disorder. His cerebrospinal fluid anti-GABAB receptor antibody titer was elevated. F-18-FDG PET/CT revealed pronounced medial temporal hypermetabolism with gross hypometabolism in the rest of the brain. There were no associated abnormalities on MRI. He showed improvement after immunotherapy and chemoradiotherapy.
引用
收藏
页码：515 / 517
页数：3
相关论文
共 12 条
  • [1] Role of FDG-PET in the clinical management of paraneoplastic neurological syndrome: Detection of the underlying malignancy and the brain PET-MRI correlates
    Basu, Sandip
    Alavi, Abass
    [J]. MOLECULAR IMAGING AND BIOLOGY, 2008, 10 (03) : 131 - 137
  • [2] Paraneoplastic encephalitis associated with cystic teratoma is detected by fluorodeoxyglucose positron emission tomography with negative magnetic resonance image findings
    Dadparvar, S
    Anderson, GS
    Bhargava, P
    Guan, L
    Reich, P
    Alavi, A
    Zhuang, HM
    [J]. CLINICAL NUCLEAR MEDICINE, 2003, 28 (11) : 893 - 896
  • [3] Limbic encephalitis and hyperactive foci on PET scan
    Fakhoury, T
    Abou-Khalil, B
    Kessler, RM
    [J]. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 1999, 8 (07): : 427 - 430
  • [4] Two Different 18F-FDG Brain PET Metabolic Patterns in Autoimmune Limbic Encephalitis
    Fisher, Ronald E.
    Patel, Niraj R.
    Lai, Eugene C.
    Schulz, Paul E.
    [J]. CLINICAL NUCLEAR MEDICINE, 2012, 37 (09) : E213 - E218
  • [5] 18F-FDG PET/CT Findings in Voltage-Gated Potassium Channel Limbic Encephalitis
    Kamaleshwaran, Koramadai Karuppuswamy
    Iyer, Rajesh Shankar
    Antony, Joppy
    Radhakrishnan, Edathuruthy Kalarickal
    Shinto, Ajit
    [J]. CLINICAL NUCLEAR MEDICINE, 2013, 38 (05) : 392 - 394
  • [6] Clinical manifestations and outcomes of the treatment of patients with GABAB encephalitis
    Kim, Tae-Joon
    Lee, Soon-Tae
    Shin, Jung-Won
    Moon, Jangsup
    Lim, Jung-Ah
    Byun, Jung-Ick
    Shin, Yong-Won
    Lee, Keon-Joo
    Jung, Keun-Hwa
    Kim, Young-Soo
    Park, Kyung-Il
    Chu, Kon
    Lee, Sang Kun
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2014, 270 (1-2) : 45 - 50
  • [7] Encephalitis and antibodies to synaptic and neuronal cell surface proteins
    Lancaster, Eric
    Martinez-Hernandez, Eugenia
    Dalmau, Josep
    [J]. NEUROLOGY, 2011, 77 (02) : 179 - 189
  • [8] Correlative Imaging With 18F-FDG PET/CT and MRI in Paraneoplastic Limbic Encephalitis
    Maffione, Anna Margherita
    Chondrogiannis, Sotirios
    Ferretti, Alice
    Al-Nahhas, Adil
    Rubello, Domenico
    [J]. CLINICAL NUCLEAR MEDICINE, 2013, 38 (06) : 463 - 464
  • [9] Striatal hypermetabolism in limbic encephalitis
    Rey, Caroline
    Koric, Lejla
    Guedj, Eric
    Felician, Olivier
    Kaphan, Elsa
    Boucraut, Jose
    Ceccaldi, Mathieu
    [J]. JOURNAL OF NEUROLOGY, 2012, 259 (06) : 1106 - 1110
  • [10] Rosenfeld Myrna R, 2012, Neurol Clin Pract, V2, P215
12