Common Mechanisms Linking Chronic Obstructive Pulmonary Disease and Lung Cancer

被引：19

作者：

Houghton, A. McGarry ^{[1
,2
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Clin Res Div, 1100 Fairview Ave N,D4-100, Seattle, WA 98109 USA

[2] Univ Washington, Div Pulm & Crit Care Med, Seattle, WA 98195 USA

来源：

ANNALS OF THE AMERICAN THORACIC SOCIETY | 2018年 / 15卷

关键词：

COPD; lung cancer; immunology; IMMUNE CELL COMPOSITION; MACROPHAGE ELASTASE; EMPHYSEMA; RISK; COPD; EXPRESSION; LANDSCAPE; BLOCKADE;

D O I：

10.1513/AnnalsATS.201808-537MG

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Chronic obstructive pulmonary disease (COPD) and lung cancer are linked diseases, with both the incidence of and risk of death from non-small cell lung cancer being increased by the presence of COPD. Despite numerous well-performed epidemiological studies having described this link over the past 30 years, the operative mechanisms remain elusive. One of the major obstacles to advancement in the field has been the lack of patient cohorts that have been phenotyped for both COPD and lung cancer. This review discusses several studies performed over the past few years highlighting the impact of COPD on the outcomes of patients with non-small cell lung cancer with respect to lung cancer screening, immune-based therapies, and lung cancer chemoprevention.

引用

页码：S273 / S277

页数：5

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