Recent advances in nanomaterial-enhanced enzyme-linked immunosorbent assays

被引：59

作者：

Gao, Lu ^{[1
]}

Yang, Qianfan ^{[1
]}

Wu, Peng ^{[1
]}

Li, Feng ^{[1
,2
]}

机构：

[1] Sichuan Univ, Key Lab Green Chem & Technol, Minist Educ, Coll Chem,Analyt & Testing Ctr, 29 Wangjiang Rd, Chengdu 610064, Sichuan, Peoples R China

[2] Brock Univ, Dept Chem, 1812 Sir Isaac Brock Way, St Catharines, ON L3S 3A1, Canada

来源：

ANALYST | 2020年 / 145卷 / 12期

关键词：

HYBRIDIZATION-CHAIN-REACTION; PEROXIDASE-LIKE ACTIVITY; ULTRASENSITIVE DETECTION; GOLD NANOPARTICLE; PLASMONIC-ELISA; COLORIMETRIC DETECTION; DISEASE BIOMARKERS; PROTEIN-DETECTION; DNA; IMMUNOASSAY;

D O I：

10.1039/d0an00597e

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Despite serving as a gold standard for protein analysis, the classic enzyme-linked immunosorbent assay (ELISA) is currently challenged by the ever-increasing needs of sensitivity and simplicity. Towards the ongoing needs, recent advances in nanomaterials have offered numerous promising tools for enhancing the performance and broadening the applicability of ELISA. In this review, we highlight nanomaterial-enabled strategies that drastically improve the assay performance without significantly altering the classic ELISA format. Particular attention will be focused on the functional roles of nanomaterials as novel readout systems in ELISA, including those serving as substrate-alternatives, enzyme-alternatives, and non-enzymatic signal amplifiers.

引用

页码：4069 / 4078

页数：10

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