Protective Effects of L-2-Oxothiazolidine-4-Carboxylate during Isoproterenol-Induced Myocardial Infarction in Rats: In Vivo Study

被引：3

作者：

Angelovski, Marija ^{[1
]}

Hadzi-Petrushev, Nikola ^{[1
]}

Atanasov, Dino ^{[1
]}

Nikodinovski, Aleksandar ^{[2
]}

Mitrokhin, Vadim ^{[3
]}

Avtanski, Dimiter B. ^{[4
]}

Mladenov, Mitko ^{[1
,3
]}

机构：

[1] Ss Cyril & Methodius Univ Skopje, Fac Nat Sci & Math, Inst Biol, Skopje 1000, North Macedonia

[2] Ss Cyril & Methodius Univ Skopje, Med Fac, Inst Preclin & Clin Pharmacol & Toxicol, Skopje 1000, North Macedonia

[3] Russian Natl Res Med Univ, Dept Fundamental & Appl Physiol, Moscow 117997, Russia

[4] Northwell Hlth, Friedman Diabet Inst, Lenox Hill Hosp, 110 E 59th St, New York, NY 10022 USA

来源：

LIFE-BASEL | 2022年 / 12卷 / 10期

关键词：

2-oxothiazolidine-4-carboxylic acid; isoproterenol; myocardial infarction; oxidative stress; inflammation; OXIDATIVE STRESS; N-ACETYLCYSTEINE; LIPID-PEROXIDATION; KAPPA-B; ACID; GLUTATHIONE; HEART; ANTIOXIDANTS; TISSUES; INJURY;

D O I：

10.3390/life12101466

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study aimed to evaluate the cardioprotective effects of L-2-oxothiazolidine-4-carboxylate (OTC) against isoproterenol (ISO)-induced acute myocardial infarction (MI) in rats. Results demonstrated that OTC treatments inhibited ISO-induced oxidative damage, suppressed lipid peroxidation, and increased superoxide dismutase and catalase activity in the hearts of the treated rats compared to those of the untreated controls. The ISO-related NF-kappa B activation was reduced due to the OTC treatment, and lower degrees of inflammatory cell infiltration and necrosis in the hearts were observed. In summary, OTC treatments exerted cardioprotective effects against MI in vivo, mainly due to enhancing cardiac antioxidant activity.

引用

页数：9

共 44 条

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