Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery

被引：11

作者：

Arai, Eri N. ^{[1
]}

Yoneda, Satoshi ^{[1
]}

Yoneda, Noriko ^{[1
]}

Ito, Mika ^{[1
]}

Tsuda, Sayaka ^{[1
]}

Shiozaki, Arihiro ^{[1
]}

Nohira, Tomoyoshi ^{[2
]}

Hyodo, Hironobu ^{[3
]}

Kumazawa, Kazumasa ^{[4
]}

Suzuki, Tomo ^{[5
]}

Nagasaki, Sumito ^{[6
]}

Makino, Shintaro ^{[7
]}

Saito, Shigeru ^{[1
]}

机构：

[1] Univ Toyama, Dept Obstet & Gynecol, Toyama, Japan

[2] Tokyo Med Univ, Dept Obstet & Gynecol, Tokyo, Japan

[3] Tokyo Metropolitan Bokutoh Hosp, Dept Obstet & Gynecol, Tokyo, Japan

[4] Natl Hosp Org Okayama Med Ctr, Dept Obstet & Gynecol, Okayama, Japan

[5] Natl Ctr Child Hlth & Dev, Ctr Maternal Fetal Neonatal & Reprod Med, Div Obstet, Tokyo, Japan

[6] Toho Univ, Dept Obstet & Gynecol, Omori Med Ctr, Tokyo, Japan

[7] Juntendo Univ, Dept Obstet & Gynecol, Urayasu Hosp, Chiba, Japan

来源：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | 2022年 / 48卷 / 03期

关键词：

Clostridium; multicenter study; preterm delivery; probiotics; recurrent spontaneous preterm delivery; REGULATORY T-CELLS; LABOR;

D O I：

10.1111/jog.15166

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Aim A large cohort study of Japanese women reported that the rate of recurrent spontaneous preterm delivery (sPTD) in the next pregnancy was 22.3%; therefore, it is important to prevent recurrent sPTD. The present study investigated the rate of recurrent sPTD in pregnant women treated with probiotics. Methods This was a retrospective study. Fifty-one pregnant women with a history of sPTD and who had been taking probiotics before 14 weeks of gestation were selected. The rate of sPTD in the next pregnancy among 255 pregnant women with a history of sPTD who had not taken probiotics was compared with that in the probiotics group. Results The rate of recurrent sPTD was 9.8% (5/51), which was lower than previously reported values. Furthermore, the rate of recurrent sPTD was significantly lower in the probiotics group (9.8%) than in the nonprobiotics group (31.0% [79/255]; p = 0.002). Conclusions Probiotics may reduce the rate of recurrent sPTD.

引用

页码：688 / 693

页数：6

共 26 条

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