Differential T-Cell Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in mRNA-1273-and BNT162b2-Vaccinated Individuals

被引：6

作者：

Gallagher, Kathleen M. E. ^{[1
,2
,3
]}

Leick, Mark B. ^{[2
,4
]}

Larson, Rebecca C. ^{[2
,4
]}

Berger, Trisha R. ^{[2
]}

Katsis, Katelin ^{[1
,2
]}

Yam, Jennifer Y. ^{[1
,2
]}

Maus, Marcela, V ^{[2
,4
]}

机构：

[1] Massachusetts Gen Hosp, Immune Monitoring Lab, Canc Ctr, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Cellular Immunotherapy Progarm, Canc Ctr, Boston, MA 02114 USA

[3] Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA

[4] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 75卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SARS-CoV2 mRNA vaccine; T-cell response; T-cell immunity; mRNA-1273; BNT162b2;

D O I：

10.1093/cid/ciac201

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

COVID-19 breakthrough cases among vaccinated individuals demonstrate the value of measuring long-term immunity to SARS-CoV-2 and its variants. We demonstrate that anti-spike T-cell responses and IgG antibody levels are maintained but decrease over time and are lower in BNT162b2- versus mRNA-1273-vaccinated individuals. T-cell responses to the variants are relatively unaffected.

引用

页码：E869 / E873

页数：5

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