Microwave-Promoted Michael Addition of Azaheterocycles to α,β-Unsaturated Esters and Acid under Solvent-Free Conditions

被引：10

作者：

Dubois, Lilian ^{[1
]}

Acher, Francine C. ^{[1
]}

McCort-Tranchepain, Isabelle ^{[1
]}

机构：

[1] Univ Paris 05, UMR CNRS 8601, Chim & Biochim Pharmacol & Toxicol Lab, F-75270 Paris 06, France

来源：

SYNLETT | 2012年 / 05期

关键词：

microwave irradiation; Michael addition; azaheterocycles; phase-transfer catalysis; green chemistry; PURINE NUCLEOBASES; HIGHLY EFFICIENT; ALKYLATION; INDOLES; GREEN; IRRADIATION; DERIVATIVES; PYRIMIDINE; CATALYST; ANALOGS;

D O I：

10.1055/s-0031-1290164

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective Michael addition of N-9 adenine to ethyl acrylate under microwave activation in solid-liquid solvent-free phase-transfer catalysis using TBAB as catalyst and DABCO as base was extended to tert-butyl acrylate and acrylic acid. Under these conditions and in the presence of a catalytic amount of KOH, first Michael addition of indole and indolylmaleimide to acrylates is also reported.

引用

收藏

页码：791 / 795

页数：5

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