Uric Acid and Risk of Atrial Fibrillation in the Korean General Population

被引:22
作者
Kwon, Chang Hee [1 ]
Lee, Sung Ho [2 ]
Lee, Jong-Young [2 ]
Ryu, Seungho [3 ]
Sung, Ki-Chul [2 ]
机构
[1] Konkuk Univ, Sch Med, Med Ctr, Div Cardiol, Seoul, South Korea
[2] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Div Cardiol,Dept Med, Seoul, South Korea
[3] Sungkyunkwan Univ, Sch Med, Dept Occupat & Environm Med, Seoul, South Korea
关键词
Atrial fibrillation; General population; Korea; Serum uric acid; XANTHINE-OXIDASE INHIBITION; FOLLOW-UP; ALL-CAUSE; HYPERURICEMIA; ASSOCIATION; LEVEL; HEART; ALLOPURINOL; SUPEROXIDE; MORTALITY;
D O I
10.1253/circj.CJ-18-0748
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Increased serum uric acid is associated with prevalence and incidence of atrial fibrillation (AF), but there is a lack of studies on the association between serum uric acid and risk of AF in the general population. Methods and Results: We used the data from the Kangbuk Samsung Hospital health screening cohort recorded between 2002 and 2015. The primary outcome was incidence of AF diagnosed on 12-lead electrocardiography. We analyzed and compared the hazard ratios (HR) according to baseline serum uric acid quartiles. The present study involved 282,473 subjects without baseline AF. Mean follow-up was 5.4 +/- 3.6 years. During follow-up, AF was identified in 365 subjects (cumulative incidence, 0.13%). After multivariable adjustment, including that for C-reactive protein, the risk of AF was significantly higher in the upper 2 quartiles than in the lowest quartile in men (upper third quartile: adjusted HR, 1.53; 95% confidence interval [CI]: 1.11-2.89; highest quartile: HR, 1.60; 95% CI: 1.13-2.25). In women, even though AF incidence rate was very low (0.6 of 10,000 person-years), the risk of AF in the highest quartile was 6.93-fold that in the lowest quartile (95% CI: 1.53-31.29). Conclusions: Serum uric acid is significantly and positively associated with incident AF in the Korean general population.
引用
收藏
页码:2728 / +
页数:9
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