Sacrospinous hysteropexy versus vaginal hysterectomy with suspension of the uterosacral ligaments in women with uterine prolapse stage 2 or higher: multicentre randomised non-inferiority trial

被引:135
作者
Detollenaere, Renee J. [1 ,2 ]
den Boon, Jan [1 ]
Stekelenburg, Jelle [3 ]
IntHout, Joanna [4 ]
Vierhout, Mark E. [2 ]
Kluivers, Kirsten B. [2 ]
van Eijndhoven, Hugo W. F. [1 ]
机构
[1] Isala, Dept Obstet & Gynaecol, NL-8000 GK Zwolle, Netherlands
[2] Radboud Univ Nijmegen, Dept Obstet & Gynaecol, Med Ctr, NL-6525 ED Nijmegen, Netherlands
[3] Med Ctr Leeuwarden, Dept Obstet & Gynaecol, Leeuwarden, Netherlands
[4] Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, NL-6525 ED Nijmegen, Netherlands
来源
BMJ-BRITISH MEDICAL JOURNAL | 2015年 / 351卷
关键词
PELVIC ORGAN PROLAPSE; QUALITY-OF-LIFE; VAULT PROLAPSE; SURGERY; RISK; INCONTINENCE; PREVALENCE; ENTEROCELE; MANAGEMENT; DESCENT;
D O I
10.1136/bmj.h3717
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE To investigate whether uterus preserving vaginal sacrospinous hysteropexy is non-inferior to vaginal hysterectomy with suspension of the uterosacral ligaments in the surgical treatment of uterine prolapse. DESIGN Multicentre randomised controlled non-blinded non-inferiority trial. SETTING 4 non-university teaching hospitals, the Netherlands. PARTICIPANTS 208 healthy women with uterine prolapse stage 2 or higher requiring surgery and no history of pelvic floor surgery. INTERVENTIONS Treatment with sacrospinous hysteropexy or vaginal hysterectomy with suspension of the uterosacral ligaments. The predefined non-inferiority margin was an increase in surgical failure rate of 7%. MAIN OUTCOME MEASURES Primary outcome was recurrent prolapse stage 2 or higher of the uterus or vaginal vault (apical compartment) evaluated by the pelvic organ prolapse quantification system in combination with bothersome bulge symptoms or repeat surgery for recurrent apical prolapse at 12 months' follow-up. Secondary outcomes were overall anatomical recurrences, including recurrent anterior compartment (bladder) and/or posterior compartment (bowel) prolapse, functional outcome, complications, hospital stay, postoperative recovery, and sexual functioning. RESULTS Sacrospinous hysteropexy was non-inferior for anatomical recurrence of the apical compartment with bothersome bulge symptoms or repeat surgery (n=0, 0%) compared with vaginal hysterectomy with suspension of the uterosacral ligaments (n=4, 4.0%, difference -3.9%, 95% confidence interval for difference -8.6% to 0.7%). At 12 months, overall anatomical recurrences, functional outcome, quality of life, complications, hospital stay, measures on postoperative recovery, and sexual functioning did not differ between the two groups. Five serious adverse events were reported during hospital stay. None was considered to be related to the type of surgery. CONCLUSIONS Uterus preservation by sacrospinous hysteropexy was non-inferior to vaginal hysterectomy with suspension of the uterosacral ligaments for surgical failure of the apical compartment at 12 months' follow-up.
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页数:9
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