Iminophenyl Oxazolinylphenylamine for Enantioselective Cobalt-Catalyzed Hydrosilylation of Aryl Ketones

被引：45
|
作者：
Chen, Xu [1 ]
Lu, Zhan [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310058, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 18期
关键词：
ASYMMETRIC TRANSFER HYDROGENATION; 1,1-DISUBSTITUTED ALKENES; CHIRAL CATALYSTS; RATIONAL DESIGN; LIGANDS; IRON; COMPLEXES; REDUCTION; HYDROBORATION; ACETOPHENONE;
D O I：
10.1021/acs.orglett.6b02260
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new family of chiral iminophenyl oxazolinylphenylaniines (IPOPA) was designed and synthesized through three steps from commercially available starting materials. An efficient cobalt-catalyzed asymmetric hydrosilylation of simple ketones with a low catalyst loading of CoCl2 and IPOPA was developed to afford chiral alcohols in good yields with high enantioselectivities.
引用
收藏
页码：4658 / 4661
页数：4
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