Iminophenyl Oxazolinylphenylamine for Enantioselective Cobalt-Catalyzed Hydrosilylation of Aryl Ketones

被引：47

作者：

Chen, Xu ^{[1
]}

Lu, Zhan ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310058, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 18期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; 1,1-DISUBSTITUTED ALKENES; CHIRAL CATALYSTS; RATIONAL DESIGN; LIGANDS; IRON; COMPLEXES; REDUCTION; HYDROBORATION; ACETOPHENONE;

D O I：

10.1021/acs.orglett.6b02260

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new family of chiral iminophenyl oxazolinylphenylaniines (IPOPA) was designed and synthesized through three steps from commercially available starting materials. An efficient cobalt-catalyzed asymmetric hydrosilylation of simple ketones with a low catalyst loading of CoCl2 and IPOPA was developed to afford chiral alcohols in good yields with high enantioselectivities.

引用

页码：4658 / 4661

页数：4

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