Chromosomal imbalances in carcinoma showing thymus-like elements (CASTLE)

被引：13

作者：

Veits, Lothar ^{[1
]}

Mechtersheimer, Gunhild ^{[2
]}

Steger, Christina ^{[1
]}

Freitag, Jens

Mikuz, Gregor ^{[1
]}

Schmid, Kurt W. ^{[3
]}

Hofmann, Walter ^{[4
]}

Schirmacher, Peter ^{[2
]}

Hartmann, Arndt ^{[5
]}

Rieker, Ralf J. ^{[2
,5
]}

机构：

[1] Med Univ Innsbruck, Inst Pathol, A-6020 Innsbruck, Austria

[2] Univ Heidelberg Hosp, Inst Pathol, D-69120 Heidelberg, Germany

[3] Univ Hosp Essen, Inst Pathol & Neuropathol, D-45122 Essen, Germany

[4] Klinikum Memmingen, Inst Pathol, D-87700 Memmingen, Germany

[5] Univ Hosp Erlangen, Inst Pathol, D-91054 Erlangen, Germany

来源：

VIRCHOWS ARCHIV | 2011年 / 459卷 / 02期

关键词：

CASTLE; Carcinoma showing thymus-like elements; Chromosomal imbalances; CGH; EPITHELIAL TUMORS; GENETIC ABERRATIONS; THYMOMA; CLASSIFICATION; ADENOMAS; SYSTEM;

D O I：

10.1007/s00428-011-1117-7

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Carcinoma showing thymus-like elements (CASTLE) is a rare neoplasm of the thyroid gland resembling lymphoepithelioma-like and squamous cell carcinoma of the thymus and is thought to arise from ectopic thymic tissue within the thyroid gland or rudimentary branchial pouches along the thymic line. Using comparative genomic hybridization (CGH), chromosomal imbalances have been detected in several types of thymomas and thymic carcinomas. To evaluate whether there are hints of an underlying sequence in the pathogenesis of CASTLE analogue to those found in thymomas and thymic carcinomas, we evaluated four of these rare neoplasms for chromosomal imbalances using CGH. The most frequent gains were seen on chromosomal arm 1q (3/4), and losses were most frequently detected on 6p (4/4), 6q (3/4) and 16q (3/4). These CGH data show that CASTLE is characterized by chromosomal imbalances similar to those found in thymomas and thymic carcinomas and indicate a similar sequence in tumour development.

引用

页码：221 / 226

页数：6

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