Elemental sulfur mediated synthesis of benzoxazoles, benzothiazoles and quinoxalines via decarboxylative coupling of 2-hydroxy/mercapto/amino-anilines with cinnamic acids

被引：19

作者：

Guntreddi, Tirumaleswararao ^{[1
]}

Vanjari, Rajeshwer ^{[1
]}

Kumar, Saurabh ^{[1
]}

Singh, Rahul ^{[1
]}

Singh, Neetu ^{[1
]}

Kumar, Promod ^{[1
]}

Singh, Krishna Nand ^{[1
]}

机构：

[1] Banaras Hindu Univ, Dept Chem, Ctr Adv Study, Inst Sci, Varanasi 221005, Uttar Pradesh, India

来源：

RSC ADVANCES | 2016年 / 6卷 / 84期

关键词：

ONE-POT SYNTHESIS; COPPER-CATALYZED SYNTHESIS; C-H FUNCTIONALIZATION; OXIDATIVE CYCLIZATION; EFFICIENT SYNTHESIS; CARBOXYLIC-ACIDS; BOND FORMATION; AQUEOUS-MEDIA; DERIVATIVES; STRATEGY;

D O I：

10.1039/c6ra17491d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An easy and practical method has been developed for the synthesis of 2-benzylbenzoxazoles and 2-benzylbenzothiazoles using sulfur mediated decarboxylative coupling of cinnamic acids with 2-hydroxyanilines and 2-mercaptoanilines respectively under metal- and solvent-free conditions. However, the reaction of 2-aminoanilines with cinnamic acids leads to the formation of 2-arylquinoxalines under the same set of reaction conditions. The transformation is versatile and compatible with a number of functional groups.

引用

收藏

页码：81013 / 81016

页数：4

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