Baseline circulating ghrelin does not predict weight regain neither maintenance of weight loss after gastric bypass at long term

被引：10

作者：

Pellitero, Silvia ^{[1
,2
]}

Perez-Romero, Noelia ^{[3
]}

Martinez, Eva ^{[1
,2
]}

Granada, Maria L. ^{[4
]}

Moreno, Pau ^{[2
,5
]}

Balibrea, Jose M. ^{[2
,5
]}

Tarasco, Jordi ^{[2
,5
]}

Lucas, Anna ^{[1
,2
]}

Puig-Domingo, Manel ^{[1
,2
]}

机构：

[1] Univ Autonoma Barcelona, Germans Trias & Pujol Res Inst, Dept Med, Endocrinol & Nutr Serv, Badalona, Spain

[2] Univ Autonoma Barcelona, Univ Hosp, Badalona, Spain

[3] Mutua Terrassa Hosp, Dept Surg, Barcelona, Spain

[4] Univ Autonoma Barcelona, Clin Biochem Serv, Badalona, Spain

[5] Univ Autonoma Barcelona, Germans Trias & Pujol Res Inst, Dept Surg, Badalona, Spain

来源：

AMERICAN JOURNAL OF SURGERY | 2015年 / 210卷 / 02期

关键词：

Gastric bypass; Ghrelin; Leptin; Weight regain; LAPAROSCOPIC SLEEVE GASTRECTOMY; BARIATRIC SURGERY; PLASMA GHRELIN; MORBIDLY OBESE; BODY-WEIGHT; GUT HORMONES; LEPTIN; INTERVENTION; ADIPONECTIN; OPERATION;

D O I：

10.1016/j.amjsurg.2014.08.040

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BACKGROUND: Predictors of weight loss (WL) or weight regain (WR) after Roux-en-Y gastric bypass (RYGBP) are not established. The aim of this study was to analyze the usefulness of some baseline peptides (leptin, insulin, and ghrelin) as biomarkers of WL and WR in morbid obese patients after RYGBP at long term. METHODS: Seventy-six morbid obese (47 women, age 41.6 +/- 9.6 years, body mass index [BMI] 52.1 +/- 8 kg/m(2)) patients were evaluated at baseline and at 1, 2, and 6 years after surgery. RESULTS: Excess body weight loss after 6 years was of 63.9%. Age, BMI, and studied hormones at baseline or their changes over time did not predict long-term excess body weight loss. WR greater than 10% was observed in 36.8% of patients between 2 and 6 years of follow-up, but it was not correlated with BMI, age, or baseline peptide concentrations. CONCLUSION: Measurement of ghrelin, insulin, and leptin before surgery is not useful as predictors of WL or WR at long term after RYGBP. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：340 / 344

页数：5

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