Nickel-catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides

被引：3

作者：

Gao, Nanxing ^{[1
]}

Li, Yanshun ^{[1
]}

Teng, Dawei ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Coll Chem Engn, State Key Lab Base Ecochem Engn, Qingdao 266042, Peoples R China

来源：

RSC ADVANCES | 2022年 / 12卷 / 06期

关键词：

HALIDES; ACIDS;

D O I：

10.1039/d2ra00010e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structure of primary alkylated arenes plays an important role in the molecular action of drugs and natural products. The nickel/spiro-bidentate-pyox catalysed cross-electrophile coupling of aryl bromides and primary alkyl bromides was developed for the formation of the Csp(2)-Csp(3) bond, which provided an efficient method for the synthesis of primary alkylated arenes. The reactions could tolerate functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide.

引用

页码：3569 / 3572

页数：4

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