Cyclopentanoid monoterpenes from the whole plant of Rehmannia piasezkii maxim

被引：7

作者：

Zhou, Jie ^{[1
]}

Shi, Guoru ^{[1
]}

Zhang, Wanqi ^{[1
]}

Li, Li ^{[1
]}

Chen, Ruoyun ^{[1
]}

Liu, Yanfei ^{[1
]}

Yu, Dequan ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

来源：

PHYTOCHEMISTRY | 2022年 / 203卷

关键词：

Rehmannia piasezkii; Plantaginaceae; Cyclopentanoid monoterpenes; Hepatoprotective activity; IRIDOID GLYCOSIDES; ROOTS; GLUCOSIDES; SESQUITERPENES; RADIX;

D O I：

10.1016/j.phytochem.2022.113316

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twelve undescribed cyclopentanoid monoterpenes, Jiopiasins A-K and 6-epi-rehmaglutin A, and 19 known compounds were isolated from the whole plant of Rehmannia piasezkii Maxim. The structures of these compounds, especially their absolute stereochemistry, were established by extensive spectroscopic analysis, various quantum chemical calculations, and/or X-ray diffraction analyses. Furthermore, in vitro assays, some compounds exhibited moderate hepatoprotective activities against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage.

引用

页数：9

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