Immune and Genome Engineering as the Future of Transplantable Tissue

被引：38

作者：

Elisseeff, Jennifer ^{[1
,2
]}

Badylak, Stephen F. ^{[3
]}

Boeke, Jef D. ^{[4
,5
,6
]}

机构：

[1] Johns Hopkins Univ, Wilmer Eye Inst, Translat Tissue Engn Ctr, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA

[3] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA

[4] NYU Langone Hlth, Inst Syst Genet, New York, NY USA

[5] NYU Langone Hlth, Dept Biochem & Mol Pharmacol, New York, NY USA

[6] NYU Tandon Sch Engn, Dept Biomed Engn, New York, NY USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2021年 / 385卷 / 26期

关键词：

ENDOGENOUS RETROVIRUS; TRANSGENIC EXPRESSION; CELLS; MATRIX; XENOTRANSPLANTATION; MACROPHAGES; PANCREAS; ANTIBODY; MODELS; DECADE;

D O I：

10.1056/NEJMra1913421

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transplantable Tissue - Immune and Genome Engineering Dramatic advancements in the use of synthetic and mechanical devices to replace tissues have been made, but restoring tissue and organ structure and function remains challenging. This review discusses the origins, innovations, and future of regenerative medicine and transplantation, which are closely intertwined.

引用

页码：2451 / 2462

页数：12

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