A role for AT1 receptor-associated proteins in blood pressure regulation

被引：9

作者：

Castrop, Hayo ^{[1
]}

机构：

[1] Univ Regensburg, Inst Physiol, D-93053 Regensburg, Germany

来源：

CURRENT OPINION IN PHARMACOLOGY | 2015年 / 21卷

关键词：

II TYPE-1 RECEPTOR; RENIN-ANGIOTENSIN SYSTEM; MUSCLE-CELL-GROWTH; INTERACTING MOLECULE; MEDIATED HYPERTENSION; CARDIAC-HYPERTROPHY; KIDNEY; ATRAP; ACTIVATION; ARAP1;

D O I：

10.1016/j.coph.2014.12.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The renin angiotensin-system is one of the most important humoral regulators of blood pressure. The recently discovered angiotensin receptor-associated proteins serve as local modulators of the renin angiotensin-system. These proteins interact with the AT1 receptor in a tissue-specific manner and regulate the sensitivity of the target cell for angiotensin II. The predominant effect of the AT1 receptor-associated proteins on angiotensin II-induced signaling is the modulation of the surface expression of the AT1 receptor. This review provides an overview of our current knowledge with respect to the relevance of AT1 receptor-associated proteins for blood pressure regulation. Two aspects of blood pressure regulation will be discussed in detail: angiotensin II-dependent volume homoeostasis and vascular resistance.

引用

页码：43 / 47

页数：5

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