Glycogen synthase kinase-3 as a key regulator of cognitive function

被引：36

作者：

Fan, Xuhong ^{[1
]}

Zhao, Zhenyu ^{[4
]}

Wang, Deming ^{[1
]}

Xiao, Ji ^{[1
,2
,3
]}

机构：

[1] Univ South China, Dept Anesthesiol, Affiliated Hosp 2, Hengyang 421001, Peoples R China

[2] Wenzhou Med Univ, Dept Anesthesia & Crit Care, Affiliated Hosp 2, Wenzhou 325027, Peoples R China

[3] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China

[4] Hunan Univ Chinese Med, Dept Anesthesiol, Hosp 1, Changsha 410000, Peoples R China

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2020年 / 52卷 / 03期

基金：

中国国家自然科学基金;

关键词：

GSK-3; cognitive function; neuroinflammation; neurogenesis; synaptic plasticity; ALZHEIMERS-DISEASE; PROTEIN-KINASE; SYNAPTIC PLASTICITY; TAU PHOSPHORYLATION; OXIDATIVE STRESS; BETA-CATENIN; MOUSE MODEL; CHOLINE-ACETYLTRANSFERASE; HIPPOCAMPAL NEUROGENESIS; INSULIN-RESISTANCE;

D O I：

10.1093/abbs/gmz156

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycogen synthase kinase-3 (GSK-3) is a highly conserved and multifunctional serine/threonine protein kinase widely distributed in eukaryotic cells. GSK-3 is originally thought to be an enzyme that regulates glycogen synthesis. It was subsequently found that GSK-3 influences many critical cellular functions, such as cell structure, neural plasticity, gene expression, and neuronal survival. Recently, GSK-3 has been found to be associated with cognition, and its dysregulation leads to cognitive impairments in many diseases, including Alzheimer's disease, diabetes, depression, Parkinson's disease, and others. In this review, we summarized the current knowledge about the structure of GSK-3, the regulation of GSK-3 activity, and its role in cognitive function and cognitiverelated disease.

引用

页码：219 / 230

页数：12

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