Innovative Preparation of Curcumin for Improved Oral Bioavailability

被引：327

作者：

Sasaki, Hiroki ^{[2
]}

Sunagawa, Yoichi ^{[1
,3
,4
]}

Takahashi, Kenji ^{[2
]}

Imaizumi, Atsushi ^{[2
]}

Fukuda, Hiroyuki ^{[2
]}

Hashimoto, Tadashi ^{[2
]}

Wada, Hiromichi ^{[3
]}

Katanasaka, Yasufumi ^{[1
]}

Kakeya, Hideaki ^{[5
]}

Fujita, Masatoshi ^{[4
]}

Hasegawa, Koji ^{[3
]}

Morimoto, Tatsuya ^{[1
]}

机构：

[1] Univ Shizuoka, Div Mol Med, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan

[2] THERAVALUES CORP, Chiyoda Ku, Tokyo 1020094, Japan

[3] Natl Hosp Org, Div Translat Res, Kyoto Med Ctr, Fushimi Ku, Kyoto 6128555, Japan

[4] Kyoto Univ, Dept Human Hlth Sci, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan

[5] Kyoto Univ, Dept Syst Chemotherapy & Mol Sci, Div Bioinformat & Chem Genom, Grad Sch Pharmaceut Sci,Sakyo Ku, Kyoto 6068501, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2011年 / 34卷 / 05期

关键词：

curcumin; bioavailability; nano-particle colloidal dispersion; absorption efficiency; I CLINICAL-TRIAL;

D O I：

10.1248/bpb.34.660

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Curcumin is a polyphenol that is commonly used for its perceived health benefits. However, the absorption efficacy of curcumin is too low to exhibit beneficial effects. We have successfully developed a highly absorptive curcumin dispersed with colloidal nano-particles, and named it THERACURMIN. The absorption efficacy of THERACURMIN was investigated and compared with that of curcumin powder. The area under the blood concentration time curve (AUC) after the oral administration of THERACURMIN was found to be more than 40-fold higher than that of curcumin powder in rats. Then, healthy human volunteers were administered orally 30 mg of THERACURMIN or curcumin powder. The AUC of THERACURMIN was 27-fold higher than that of curcumin powder. In addition, THERACURMIN exhibited an inhibitory action against alcohol intoxication after drinking in humans, as evidenced by the reduced acetaldehyde concentration of the blood. These findings demonstrate that THERACURMIN shows a much higher bioavailability than currently available preparations. Thus, THERACURMIN may be useful to exert clinical benefits in humans at a lower dosage.

引用

页码：660 / 665

页数：6

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