Dual Synergistic Effects of MgO-GO Fillers on Degradation Behavior, Biocompatibility and Antibacterial Activities of Chitosan Coated Mg Alloy

被引:11
作者
Baghbaderani, Mohammad Zolfaghari [1 ]
Abazari, Somayeh [2 ,3 ]
Bakhsheshi-Rad, Hamid Reza [1 ]
Ismail, Ahmad Fauzi [4 ]
Sharif, Safian [5 ]
Najafinezhad, Aliakbar [1 ]
Ramakrishna, Seeram [6 ]
Daroonparvar, Mohammadreza [7 ]
Berto, Filippo [8 ]
机构
[1] Islamic Azad Univ, Adv Mat Res Ctr, Dept Mat Engn, Najafabad Branch, Najafabad, Iran
[2] Amirkabir Univ Technol, Dept Mat & Met Engn, Tehran, Iran
[3] Iranian Natl Stand Org, Tehran, Iran
[4] Univ Teknol Malaysia, Adv Membrane Technol Res Ctr AMTEC, Johor Baharu 81310, Johor, Malaysia
[5] Univ Teknol Malaysia, Fac Engn, Johor Baharu 81310, Johor, Malaysia
[6] Natl Univ Singapore, Dept Mech Engn, 9 Engn Dr 1, Singapore 117576, Singapore
[7] Univ Nevada, Dept Chem & Mat Engn, Reno, NV 89501 USA
[8] Norwegian Univ Sci & Technol, Dept Mech & Ind Engn, N-7491 Trondheim, Norway
关键词
magnesium alloy; composite coating; structural characterization; mechanical properties; bioactivity; antibacterial activity; biocompatibility; ELECTROPHORETIC DEPOSITION; MECHANICAL-PROPERTIES; COMPOSITE COATINGS; MAGNESIUM ALLOY; BIOMEDICAL APPLICATIONS; CORROSION-RESISTANCE; AZ31; HYDROXYAPATITE; TITANIUM; AG;
D O I
10.3390/coatings12010063
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
The aim of this work was to establish and characterize chitosan/graphene oxide- magnesium oxide (CS/GO-MgO) nanocomposite coatings on biodegradable magnesium-zinc-cerium (Mg-Zn-Ce) alloy. In comparison to that of pure CS coatings, all composite coatings encapsulating GO-MgO had better adhesion strength to the Mg-Zn-Ce alloy substrate. The result depicted that the co-encapsulation of GO-MgO into the CS layer leads to diminish of contact angle value and hence escalates the hydrophilic characteristic of coated Mg alloy. The electrochemical test demonstrated that the CS/GO-MgO coatings significantly increased the corrosion resistance because of the synergistic effect of the GO and MgO inside the CS coating. The composite coating escalated cell viability and cell differentiation, according to cytocompatibility tests due to the presence of GO and MgO within the CS. The inclusion of GO-MgO in CS film, on the other hand, accelerates the formation of hydroxyapatite (HA) during 14 days immersion in SBF. Immersion results, including weight loss and hydrogen evolution tests, presented that CS/GO-MgO coating enables a considerably reduced degradation rate of Mg-Zn-Ce alloy when compared to the bare alloy. In terms of antibacterial-inhibition properties, the GO-MgO/CS coatings on Mg substrates showed antibacterial activity against Escherichia coli (E. coli), with a large inhibition area around the specimens, particularly for the coating containing a higher concentration of GO-MgO. Bacterial growth was not inhibited by the bare Mg alloy samples. The CS/GO-MgO composite coating is regarded as a great film to enhance the corrosion resistance, bioactivity, and antibacterial performance of Mg alloy implants.
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页数:17
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