Magnetically separable nano-copper catalyzed unprecedented stereoselective synthesis of E-vinyl sulfones from tosylmethyl isocyanide and alkynes: TosMIC as a source of the sulfonyl group

被引：42

作者：

Phanindrudu, Mandalaparthi ^{[1
]}

Tiwari, Dipak Kumar ^{[1
]}

Sridhar, B. ^{[2
]}

Likhar, Pravin R. ^{[1
]}

Tiwari, Dharmendra Kumar ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Inorgan & Phys Chem Div, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India

[2] Indian Inst Chem Technol, CSIR, Xray Crystallog Ctr, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India

来源：

ORGANIC CHEMISTRY FRONTIERS | 2016年 / 3卷 / 07期

关键词：

CYSTEINE PROTEASE INHIBITORS; ENANTIOSELECTIVE CONJUGATE ADDITION; DIPEPTIDYL PEPTIDASE-I; ALPHA; BETA-UNSATURATED SULFONES; PROPARGYLIC ALCOHOLS; ASYMMETRIC ADDITION; DUAL ROLES; ACIDS; DERIVATIVES; DISCOVERY;

D O I：

10.1039/c6qo00063k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed an unprecedented efficient and mild catalytic route for stereoselective synthesis of E-vinyl sulfones from terminal alkynes and tosylmethyl isocyanide (TosMIC) in the presence of magnetically separable nano-copper (0) stabilized on Fe3O4. A variety of vinyl sulfones were obtained in moderate to good yields. In this newly developed protocol TosMIC acts as a sulfonyl source. The catalyst was magnetically removed and recycled easily five times without any appreciable loss in activity.

引用

页码：795 / 798

页数：4