Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery

被引：341

作者：

Oller-Salvia, Benjami ^{[1
]}

Sanchez-Navarro, Macarena ^{[1
]}

Giralt, Ernest ^{[1
,2
]}

Teixido, Meritxell ^{[1
]}

机构：

[1] Barcelona Inst Sci & Technol BIST, Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain

[2] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain

来源：

CHEMICAL SOCIETY REVIEWS | 2016年 / 45卷 / 17期

关键词：

CENTRAL-NERVOUS-SYSTEM; DENSITY-LIPOPROTEIN RECEPTOR; TARGETED DRUG-DELIVERY; POLY(ETHYLENE GLYCOL)-CO-POLY(EPSILON-CAPROLACTONE) NANOPARTICLES; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GLUTATHIONE PEGYLATED LIPOSOMES; HUMAN TRANSFERRIN RECEPTOR; CELL-PENETRATING PEPTIDES; THERAPEUTIC-EFFICACY; POLYMERIC MICELLES;

D O I：

10.1039/c6cs00076b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Brain delivery is one of the major challenges in drug development because of the high number of patients suffering from neural diseases and the low efficiency of the treatments available. Although the blood-brain barrier (BBB) prevents most drugs from reaching their targets, molecular vectors - known as BBB shuttles - offer great promise to safely overcome this formidable obstacle. In recent years, peptide shuttles have received growing attention because of their lower cost, reduced immunogenicity, and higher chemical versatility than traditional Trojan horse antibodies and other proteins.

引用

页码：4690 / 4707

页数：18

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