Phosphodiesterase type 5 and cancers: progress and challenges

被引:48
作者
Barone, Ines [1 ]
Giordano, Cinzia [2 ]
Bonofiglio, Daniela [1 ]
Ando, Sebastiano [1 ]
Catalano, Stefania [1 ]
机构
[1] Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Italy
[2] Univ Calabria, Ctr Sanit, Arcavacata Di Rende, CS, Italy
关键词
phosphodiesterase; cancer; targeted therapy; biomarkers; chemoprevention; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; CELL LUNG-CANCER; URINARY-TRACT SYMPTOMS; ALLOSTERIC CGMP-BINDING; PDE5 INHIBITORS ENHANCE; SKIN FLAP SURVIVAL; ERECTILE DYSFUNCTION; PROSTATE-CANCER; SILDENAFIL CITRATE; SULINDAC SULFONE;
D O I
10.18632/oncotarget.21837
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancers are an extraordinarily heterogeneous collection of diseases with distinct genetic profiles and biological features that directly influence response patterns to various treatment strategies as well as clinical outcomes. Nevertheless, our growing understanding of cancer cell biology and tumor progression is gradually leading towards rational, tailored medical treatments designed to destroy cancer cells by exploiting the unique cellular pathways that distinguish them from normal healthy counterparts. Recently, inhibition of the activity of phosphodiesterase type 5 (PDE5) is emerging as a promising approach to restore normal intracellular cyclic guanosine monophosphate (cGMP) signalling, and thereby resulting into the activation of various downstream molecules to inhibit proliferation, motility and invasion of certain cancer cells. In this review, we present an overview of the experimental and clinical evidences highlighting the role of PDE5 in the pathogenesis and prevention of various malignancies. Current data are still not sufficient to draw conclusive statements for cancer patient management, but could provide further rational for testing PDE5-targeting drugs as anticancer agents in clinical settings.
引用
收藏
页码:99179 / 99202
页数:24
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