共 281 条
Phosphodiesterase type 5 and cancers: progress and challenges
被引:48
作者:

Barone, Ines
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Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Italy Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Italy

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Bonofiglio, Daniela
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Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Italy Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Italy

Ando, Sebastiano
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Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Italy Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Italy

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机构:
[1] Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Italy
[2] Univ Calabria, Ctr Sanit, Arcavacata Di Rende, CS, Italy
来源:
关键词:
phosphodiesterase;
cancer;
targeted therapy;
biomarkers;
chemoprevention;
CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES;
CELL LUNG-CANCER;
URINARY-TRACT SYMPTOMS;
ALLOSTERIC CGMP-BINDING;
PDE5 INHIBITORS ENHANCE;
SKIN FLAP SURVIVAL;
ERECTILE DYSFUNCTION;
PROSTATE-CANCER;
SILDENAFIL CITRATE;
SULINDAC SULFONE;
D O I:
10.18632/oncotarget.21837
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Cancers are an extraordinarily heterogeneous collection of diseases with distinct genetic profiles and biological features that directly influence response patterns to various treatment strategies as well as clinical outcomes. Nevertheless, our growing understanding of cancer cell biology and tumor progression is gradually leading towards rational, tailored medical treatments designed to destroy cancer cells by exploiting the unique cellular pathways that distinguish them from normal healthy counterparts. Recently, inhibition of the activity of phosphodiesterase type 5 (PDE5) is emerging as a promising approach to restore normal intracellular cyclic guanosine monophosphate (cGMP) signalling, and thereby resulting into the activation of various downstream molecules to inhibit proliferation, motility and invasion of certain cancer cells. In this review, we present an overview of the experimental and clinical evidences highlighting the role of PDE5 in the pathogenesis and prevention of various malignancies. Current data are still not sufficient to draw conclusive statements for cancer patient management, but could provide further rational for testing PDE5-targeting drugs as anticancer agents in clinical settings.
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页码:99179 / 99202
页数:24
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共 281 条
[51]
PDE5 Inhibitors-Loaded Nanovesicles: Physico-Chemical Properties and In Vitro Antiproliferative Activity
[J].
De Rose, Roberta F.
;
Cristiano, Maria Chiara
;
Celano, Marilena
;
Maggisano, Valentina
;
Vero, Ada
;
Lombardo, Giovanni Enrico
;
Di Francesco, Martina
;
Paolino, Donatella
;
Russo, Diego
;
Cosco, Donato
.
NANOMATERIALS,
2016, 6 (05)

De Rose, Roberta F.
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy

Cristiano, Maria Chiara
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy

Celano, Marilena
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy

Maggisano, Valentina
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy

Vero, Ada
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy

Lombardo, Giovanni Enrico
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy

Di Francesco, Martina
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy

Paolino, Donatella
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy

Russo, Diego
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy

Cosco, Donato
论文数: 0 引用数: 0
h-index: 0
机构:
Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Univ S Venuta,Viale S Venuta, I-88100 Catanzaro, Italy
[52]
Role of sildenafil in acute posttransplant right ventricular dysfunction: Successful experience in 13 consecutive patients
[J].
De Santo, L. S.
;
Mastroianni, C.
;
Romano, G.
;
Amarelli, C.
;
Marra, C.
;
Maiello, C.
;
Galdieri, N.
;
Della Corte, A.
;
Cotrufo, M.
;
Caianiello, G.
.
TRANSPLANTATION PROCEEDINGS,
2008, 40 (06)
:2015-2018

De Santo, L. S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Foggia, Sch Med, Foggia, Italy Univ Foggia, Sch Med, Foggia, Italy

Mastroianni, C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Naples 2, Dept Cardiothorac Surg, Naples, Italy Univ Foggia, Sch Med, Foggia, Italy

Romano, G.
论文数: 0 引用数: 0
h-index: 0
机构:
V Monaldi Hosp, Dept Cardiovasc Surg & Transplant, Naples, Italy Univ Foggia, Sch Med, Foggia, Italy

Amarelli, C.
论文数: 0 引用数: 0
h-index: 0
机构:
V Monaldi Hosp, Dept Cardiovasc Surg & Transplant, Naples, Italy Univ Foggia, Sch Med, Foggia, Italy

Marra, C.
论文数: 0 引用数: 0
h-index: 0
机构:
V Monaldi Hosp, Dept Cardiovasc Surg & Transplant, Naples, Italy Univ Foggia, Sch Med, Foggia, Italy

Maiello, C.
论文数: 0 引用数: 0
h-index: 0
机构:
V Monaldi Hosp, Dept Cardiovasc Surg & Transplant, Naples, Italy Univ Foggia, Sch Med, Foggia, Italy

Galdieri, N.
论文数: 0 引用数: 0
h-index: 0
机构:
V Monaldi Hosp, Dept Cardiovasc Surg & Transplant, Naples, Italy Univ Foggia, Sch Med, Foggia, Italy

Della Corte, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Naples 2, Dept Cardiothorac Surg, Naples, Italy Univ Foggia, Sch Med, Foggia, Italy

Cotrufo, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Naples 2, Dept Cardiothorac Surg, Naples, Italy Univ Foggia, Sch Med, Foggia, Italy

Caianiello, G.
论文数: 0 引用数: 0
h-index: 0
机构:
V Monaldi Hosp, Dept Cardiovasc Surg & Transplant, Naples, Italy Univ Foggia, Sch Med, Foggia, Italy
[53]
Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)
[J].
Degerman, E
;
Belfrage, P
;
Manganiello, VC
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1997, 272 (11)
:6823-6826

Degerman, E
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI,PULM CRIT CARE MED BRANCH,NIH,BETHESDA,MD 20892

Belfrage, P
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI,PULM CRIT CARE MED BRANCH,NIH,BETHESDA,MD 20892

Manganiello, VC
论文数: 0 引用数: 0
h-index: 0
机构: NHLBI,PULM CRIT CARE MED BRANCH,NIH,BETHESDA,MD 20892
[54]
Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes
[J].
Desouza, C
;
Parulkar, A
;
Lumpkin, D
;
Akers, D
;
Fonseca, VA
.
DIABETES CARE,
2002, 25 (08)
:1336-1339

Desouza, C
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA

Parulkar, A
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA

Lumpkin, D
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA

Akers, D
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA

Fonseca, VA
论文数: 0 引用数: 0
h-index: 0
机构:
Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA Tulane Univ, Sch Med, Dept Med, Endocrinol Sect,Hlth Sci Ctr, New Orleans, LA 70112 USA
[55]
Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth
[J].
Dhayade, Sandeep
;
Kaesler, Susanne
;
Sinnberg, Tobias
;
Dobrowinski, Hyazinth
;
Peters, Stefanie
;
Naumann, Ulrike
;
Liu, He
;
Hunger, Robert E.
;
Thunemann, Martin
;
Biedermann, Tilo
;
Schittek, Birgit
;
Simon, Hans-Uwe
;
Feil, Susanne
;
Feil, Robert
.
CELL REPORTS,
2016, 14 (11)
:2599-2610

Dhayade, Sandeep
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Kaesler, Susanne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Dermatol, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Sinnberg, Tobias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Dermatol, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Dobrowinski, Hyazinth
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Peters, Stefanie
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Naumann, Ulrike
论文数: 0 引用数: 0
h-index: 0
机构:
Hertie Inst Klin Hirnforsch, Abt Vaskulare Neurol, Lab Mol Neuroonkol, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Liu, He
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bern, Inst Pharmacol, CH-3010 Bern, Switzerland Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Hunger, Robert E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hosp Bern, Inselspital, Dept Dermatol, CH-3010 Bern, Switzerland Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Thunemann, Martin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Biedermann, Tilo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Dermatol, D-72076 Tubingen, Germany
Tech Univ Munich, Dept Dermatol & Allergol, D-80802 Munich, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Schittek, Birgit
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Dept Dermatol, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Simon, Hans-Uwe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bern, Inst Pharmacol, CH-3010 Bern, Switzerland Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Feil, Susanne
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany

Feil, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany Univ Tubingen, Interfak Inst Biochem, D-72076 Tubingen, Germany
[56]
PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease
[J].
Diamant, Zuzana
;
Spina, Domenico
.
PULMONARY PHARMACOLOGY & THERAPEUTICS,
2011, 24 (04)
:353-360

Diamant, Zuzana
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus MC, Dept Allergol, Rotterdam, Netherlands Erasmus MC, Dept Allergol, Rotterdam, Netherlands

Spina, Domenico
论文数: 0 引用数: 0
h-index: 0
机构:
Kings Coll London, Sackler Inst Pulm Pharmacol, Inst Pharmaceut Sci, London SE1 9NH, England Erasmus MC, Dept Allergol, Rotterdam, Netherlands
[57]
Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial
[J].
Dimitriadis, Fotios
;
Tsambalas, Stavros
;
Tsounapi, Panagiota
;
Kawamura, Hiroshi
;
Vlachopoulou, Evlalia
;
Haliasos, Nikolaos
;
Gratsias, Stavros
;
Watanabe, Takeshi
;
Saito, Motoaki
;
Miyagawa, Ikuo
;
Sofikitis, Nikolaos
.
BJU INTERNATIONAL,
2010, 106 (08)
:1181-1185

Dimitriadis, Fotios
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan
Tottori Univ, Dept Pathophysiol & Therapeut Sci, Div Mol Pharmacol, Fac Med, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Tsambalas, Stavros
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Dept Pathophysiol & Therapeut Sci, Div Mol Pharmacol, Fac Med, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Tsounapi, Panagiota
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Kawamura, Hiroshi
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Dept Pathophysiol & Therapeut Sci, Div Mol Pharmacol, Fac Med, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Vlachopoulou, Evlalia
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Dept Pathophysiol & Therapeut Sci, Div Mol Pharmacol, Fac Med, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Haliasos, Nikolaos
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Dept Pathophysiol & Therapeut Sci, Div Mol Pharmacol, Fac Med, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Gratsias, Stavros
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Dept Pathophysiol & Therapeut Sci, Div Mol Pharmacol, Fac Med, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Watanabe, Takeshi
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Saito, Motoaki
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ioannina, Sch Med, Lab Mol Urol & Genet Human Reprod, Dept Urol, GR-45110 Ioannina, Greece Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Miyagawa, Ikuo
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan

Sofikitis, Nikolaos
论文数: 0 引用数: 0
h-index: 0
机构:
Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan
Tottori Univ, Dept Pathophysiol & Therapeut Sci, Div Mol Pharmacol, Fac Med, Yonago, Tottori 6838503, Japan Tottori Univ, Sch Med, Dept Urol, Yonago, Tottori 6838503, Japan
[58]
Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats
[J].
Ding, Guangliang
;
Jiang, Quan
;
Li, Lian
;
Zhang, Li
;
Zhang, Zheng Gang
;
Ledbetter, Karyn A.
;
Panda, Swayamprava
;
Davarani, Siamak P. N.
;
Athiraman, Hemanthkumar
;
Li, Qingjiang
;
Ewing, James R.
;
Chopp, Michael
.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,
2008, 28 (08)
:1440-1448

Ding, Guangliang
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Jiang, Quan
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Li, Lian
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Zhang, Li
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Zhang, Zheng Gang
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Ledbetter, Karyn A.
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Panda, Swayamprava
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Davarani, Siamak P. N.
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA
Univ Michigan, Dept Elect Engn, Ann Arbor, MI 48109 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Athiraman, Hemanthkumar
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA
Oakland Univ, Dept Phys, Rochester, MI USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Li, Qingjiang
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Ewing, James R.
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

Chopp, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA
Oakland Univ, Dept Phys, Rochester, MI USA Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA
[59]
Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes
[J].
Dong, Hongli
;
Osmanova, Venera
;
Epstein, Paul M.
;
Brocke, Stefan
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
2006, 345 (02)
:713-719

Dong, Hongli
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Connecticut, Ctr Hlth, Dept Pharmacol, Farmington, CT 06030 USA Univ Connecticut, Ctr Hlth, Dept Pharmacol, Farmington, CT 06030 USA

Osmanova, Venera
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Connecticut, Ctr Hlth, Dept Pharmacol, Farmington, CT 06030 USA Univ Connecticut, Ctr Hlth, Dept Pharmacol, Farmington, CT 06030 USA

Epstein, Paul M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Connecticut, Ctr Hlth, Dept Pharmacol, Farmington, CT 06030 USA Univ Connecticut, Ctr Hlth, Dept Pharmacol, Farmington, CT 06030 USA

Brocke, Stefan
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Univ Connecticut, Ctr Hlth, Dept Pharmacol, Farmington, CT 06030 USA Univ Connecticut, Ctr Hlth, Dept Pharmacol, Farmington, CT 06030 USA
[60]
The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5
[J].
Dunkem, TR
;
Hatzelmann, A
.
CELLULAR SIGNALLING,
2005, 17 (03)
:331-339

Dunkem, TR
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ALTANA Pharma AG, Dept RDR B2, Dept Biochem Inflammat, D-78467 Constance, Germany ALTANA Pharma AG, Dept RDR B2, Dept Biochem Inflammat, D-78467 Constance, Germany

Hatzelmann, A
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ALTANA Pharma AG, Dept RDR B2, Dept Biochem Inflammat, D-78467 Constance, Germany ALTANA Pharma AG, Dept RDR B2, Dept Biochem Inflammat, D-78467 Constance, Germany