Filaggrin mutations increase the risk for persistent dry skin and eczema independent of sensitization

被引:28
作者
Bohme, Maria [1 ,2 ]
Soderhall, Cilla [3 ]
Kull, Inger [4 ,5 ]
Bergstrom, Anna [6 ]
van Hage, Marianne [7 ,8 ]
Wahlgren, Carl-Fredrik [1 ,2 ]
机构
[1] Karolinska Univ Hosp Solna, Dept Dermatol & Venereol, Stockholm, Sweden
[2] Karolinska Inst, Dept Med, Dermatol & Venereol Unit, Stockholm, Sweden
[3] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden
[4] Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden
[5] Karolinska Inst, Ctr Allergy Res, Stockholm, Sweden
[6] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden
[7] Karolinska Univ Hosp Solna, Dept Clin Immunol, Stockholm, Sweden
[8] Karolinska Inst, Dept Med, Clin Immunol & Allergy Unit, Stockholm, Sweden
关键词
ATOPIC-DERMATITIS; BIRTH COHORT; PREDISPOSE;
D O I
10.1016/j.jaci.2011.11.032
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:1153 / 1155
页数:4
相关论文
共 8 条
[1]   Gene-environment interaction in the onset of eczema in infancy: Filaggrin loss-of-function mutations enhanced by neonatal cat exposure [J].
Bisgaard, Hans ;
Simpson, Angela ;
Palmer, Colin N. A. ;
Bonnelykke, Klaus ;
Mclean, Irwin ;
Mukhopadhyay, Somnath ;
Pipper, Christian B. ;
Halkjaer, Liselotte B. ;
Lipworth, Brian ;
Hankinson, Jenny ;
Woodcock, Ashley ;
Custovic, Adnan .
PLOS MEDICINE, 2008, 5 (06) :0934-0940
[2]   Atopic dermatitis and concomitant disease patterns in children up to two years of age [J].
Böhme, M ;
Lannerö, E ;
Wickman, M ;
Nordvall, SL ;
Wahlgren, CF .
ACTA DERMATO-VENEREOLOGICA, 2002, 82 (02) :98-103
[3]   Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth [J].
Bonnelykke, Klaus ;
Pipper, Christian B. ;
Tavendale, Roger ;
Palmer, Colin N. A. ;
Bisgaard, Hans .
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2010, 21 (06) :954-961
[4]   Elder siblings enhance the effect of filaggrin mutations on childhood eczema: Results from the 2 birth cohort studies LISAplus and GINIplus [J].
Cramer, Claudia ;
Link, Elke ;
Horster, Maike ;
Koletzko, Sibylle ;
Bauer, Carl-P. ;
Berdel, Dietrich ;
von Berg, Andrea ;
Lehmann, Irina ;
Herbarth, Olf ;
Borte, Michael ;
Schaaf, Beate ;
Behrendt, Heidrun ;
Chen, Chih-Mei ;
Sausenthaler, Stefanie ;
Illig, Thomas ;
Wichmann, H. -Erich ;
Heinrich, Joachim ;
Kraemer, Ursula .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (06) :1254-1260
[5]   Fleshing out filaggrin phenotypes [J].
Irvine, Alan D. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (03) :504-507
[6]   Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations [J].
Weidinger, Stephan ;
Illig, Thomas ;
Baurecht, Hansjoerg ;
Irvine, Alan D. ;
Rodriguez, Elke ;
Diaz-Lacava, Amalia ;
Klopp, Norman ;
Wagenpfeil, Stefan ;
Zhao, Yiwei ;
Liao, Haihui ;
Lee, Simon P. ;
Palmer, Colin N. A. ;
Jenneck, Claudia ;
Maintz, Laura ;
Hagemann, Tobias ;
Behrendt, Heidrun ;
Ring, Johannes ;
Nothen, Markus M. ;
McLean, W. H. Irwin ;
Novak, Natalija .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (01) :214-219
[7]   Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis [J].
Weidinger, Stephan ;
Rodriguez, Elke ;
Stahl, Caroline ;
Wagenpfeil, Stefan ;
Klopp, Norman ;
Illig, Thomas ;
Novak, Natalija .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (03) :724-726
[8]   The BAMSE Project: presentation of a prospective longitudinal birth cohort study [J].
Wickman, M ;
Kull, I ;
Pershagen, G ;
Nordvall, SL .
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2002, 13 :11-13