Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968

被引：34

作者：

Pisano, Claudio ^{[1
]}

De Cesare, Michelandrea ^{[2
]}

Beretta, Giovanni Luca ^{[2
]}

Zuco, Valentina ^{[2
]}

Pratesi, Graziella ^{[2
]}

Penco, Sergio ^{[1
]}

Vesci, Loredana ^{[1
]}

Fodera, Rosanna ^{[1
]}

Ferrara, Fabiana Fosca ^{[1
]}

Guglielmi, Mario Berardino ^{[1
]}

Carminati, Paolo ^{[1
]}

Dallavalle, Sabrina ^{[3
]}

Morini, Gabriella ^{[4
]}

Merlini, Lucio ^{[3
]}

Orlandi, Augusto ^{[5
]}

Zunino, Franco ^{[2
]}

机构：

[1] Sigma Tau Pharmaceut Co, Pomezia, Italy

[2] Ist Nazl Tumori, Fdn IRCCS, I-20133 Milan, Italy

[3] Univ Milan, DISMA, Milan, Italy

[4] Univ Sci Gastronom, Pollensa, Cuneo, Italy

[5] Univ Roma Tor Vergata, Rome, Italy

来源：

MOLECULAR CANCER THERAPEUTICS | 2008年 / 7卷 / 07期

关键词：

D O I：

10.1158/1535-7163.MCT-08-0266

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

ST1968 is a novel hydrophilic camptothecin (CPT) derivative of the 7-oxyiminomethyl series. Because ST1968 retained ability to form remarkably stable cleavable complexes, this study was done to investigate its preclinical profile of antitumor activity in a large panel of human tumor models, including irinotecan-resistant tumors. Although less potent than SN38 in vitro, i.v. administered ST1968 caused a marked tumor inhibition, superior to that of irinotecan, in most tested models. ST1968 exhibited an impressive activity against several tumors including models of ovarian and colon carcinoma in which a high rate of cures was observed. In the most responsive tumors, complete and persistent tumor regressions were achieved even with low suboptimal doses. Even tumors derived from intrinsically resistant cells exhibited a significant responsiveness. Histologic analysis of treated tumors supports a contribution of both proapoptotic and antiangiogenic effects to ST1968 antitumor efficacy. A study done in yeast cells transformed with CPT-resistant mutant forms of topoisomerase I documented that, in contrast to other tested CPT, ST 1968 was active against yeasts expressing the mutant K720E enzyme. Based on its outstanding efficacy superior to that of irinotecan and of its good therapeutic index, ST1968 has been selected for clinical development.

引用

页码：2051 / 2059

页数：9

共 37 条

[1] Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topolsomerase I cleavage complexes and overcome multidrug resistance [J].