Selective extraction of proteins and other macromolecules from biological samples using molecular imprinted polymers

被引：32

作者：

Stevenson, Derek ^{[1
]}

EL-Sharif, Hazim F. ^{[1
]}

Reddy, Subrayal M. ^{[2
]}

机构：

[1] Univ Surrey, Dept Chem, Guildford GU2 7XH, Surrey, England

[2] Univ Cent Lancashire, Div Chem, Preston PR1 2HE, Lancs, England

来源：

BIOANALYSIS | 2016年 / 8卷 / 21期

关键词：

antibody mimics; bioanalysis; macromolecules; molecular imprinted polymers; proteins; selective extraction; SOLID-PHASE EXTRACTION; PROGASTRIN RELEASING PEPTIDE; MASS-SPECTROMETRY; FUNCTIONALIZED SILICA; VIRUS-RECOGNITION; NANOPARTICLES; SEPARATION; ENRICHMENT; ACRYLAMIDE; HYDROGEL;

D O I：

10.4155/bio-2016-0209

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The accurate determination of intact macromolecules in biological samples, such as blood, plasma, serum, urine, tissue and feces is a challenging problem. The increased interest in macromolecules both as candidate drugs and as biomarkers for diagnostic purposes means that new method development approaches are needed. This review charts developments in the use of molecularly imprinted polymers first for small-molecular-mass compounds then for proteins and other macromolecules. Examples of the development of molecularly imprinted polymers for macromolecules are highlighted. The two main application areas to date are sensors and separation science, particularly SPE. Examples include peptides and polypeptides, lysozyme, hemoglobin, ovalbumin, bovine serum albumin and viruses.

引用

页码：2255 / 2263

页数：9

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