Primary breast diffuse large B-cell lymphoma in the era of rituximab

被引：9

作者：

Zhang, Na ^{[1
]}

Cao, Caineng ^{[1
]}

Zhu, Yuan ^{[1
]}

Liu, Peng ^{[1
]}

Liu, Luying ^{[1
]}

Lu, Ke ^{[1
]}

Luo, Jialin ^{[1
]}

Zhou, Ning ^{[1
]}

机构：

[1] Zhejiang Canc Hosp, Dept Radiat Oncol, Zhejiang Key Lab Radiat Oncol, 38 Guangji Rd, Hangzhou 310022, Zhejiang, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2016年 / 9卷

关键词：

primary breast lymphoma; diffuse large B-cell lymphoma; rituximab; prognosis; PROGNOSTIC-FACTORS; OUTCOMES; CLASSIFICATION; CHEMOTHERAPY; MULTICENTER; EXPERIENCE; COMMITTEE;

D O I：

10.2147/OTT.S108839

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background and objective: The aim of this study was to summarize the clinical characteristics and evaluate the management approaches of primary breast diffuse large B-cell lymphoma (DLBCL) in the era of rituximab. Patients and methods: A total of 24 female patients with newly diagnosed primary breast DLBCL treated between April 2006 and May 2013 were analyzed retrospectively. Ten patients (41.7%) received rituximab. Results: For the whole group, the median age was 50 years (range 24-69 years). All patients had the disease detected with a palpable mass. The estimated 5-year overall survival and progression-free survival (PFS) rates of all the patients were 78.9% and 79.2%, respectively. A nonstatistically significant increase in PFS and overall survival was observed when rituximab was administered (5-year PFS: 90% vs 71.4%, P=0.285; 5-year overall survival: 90% vs 71.4%, P=0.239). Conclusion: Primary breast DLBCL appears to be a rare disease. Adding rituximab might improve survival in patients with primary breast DLBCL. Further prospective studies are needed to evaluate the role of rituximab for primary breast DLBCL.

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收藏

页码：6093 / 6097

页数：5

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